The HA-incorporated nanostructure of a peptide-drug amphiphile for targeted anticancer drug delivery

被引：29

作者：

Choi, Huyeon ^{[1
]}

Jeena, M. T. ^{[1
]}

Palanikumar, L. ^{[1
]}

Jeong, Yoojeong ^{[2
]}

Park, Sooham ^{[1
]}

Lee, Eunji ^{[2
]}

Ryu, Ja-Hyoung ^{[1
]}

机构：

[1] Ulsan Natl Inst Sci & Technol, Sch Nat Sci, Dept Chem, Ulsan 44919, South Korea

[2] Chungnam Natl Univ, Grad Sch Analyt Sci & Technol, 99 Daehak Ro, Daejeon 305764, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 32期

基金：

新加坡国家研究基金会;

关键词：

HYALURONIC-ACID; CANCER; NANOCARRIERS; NANOTUBES; RELEASE; CATABOLISM;

D O I：

10.1039/c6cc00200e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK-CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK-CPT exhibited target specific toxicity with excellent antitumour efficiency.

引用

页码：5637 / 5640

页数：4

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