Clinical characteristics of ulcerative colitis in elderly patients

被引:5
作者
Zhu, Mingming [1 ]
Ran, Zhihua [1 ]
机构
[1] Shanghai Jiao Tong Univ, Div Gastroenterol & Hepatol,Shanghai Inst Digest, Key Lab Gastroenterol & Hepatol,Renji Hosp,Sch Me, Minist Hlth,Shanghai Inflammatory Bowel Dis Res C, Shanghai 200127, Peoples R China
来源
JGH OPEN | 2021年 / 5卷 / 08期
关键词
clinical characteristics; elderly; medical therapy; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; ANTI-TNF THERAPY; NATURAL-HISTORY; OPPORTUNISTIC INFECTIONS; SERIOUS INFECTIONS; COLORECTAL-CANCER; RISK-FACTORS; ONSET; SAFETY; VEDOLIZUMAB;
D O I
10.1002/jgh3.12612
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The incidence of ulcerative colitis (UC) in elderly patients is increasing. Elderly UC patients are likely to exhibit distinct features both at diagnosis and during follow-up. Age-related problems, including complications, immune dysfunction, and multidrug use, make the diagnosis and treatment of elderly UC more challenging. Suboptimal treatment considering adverse events leads to poor clinical outcome in elderly UC patients. Here, we reviewed the epidemiology, clinical presentation, medical therapy, colorectal cancer surveillance of UC in elderly patients.
引用
收藏
页码:849 / 854
页数:6
相关论文
共 71 条
  • [1] Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study
    Alexakis, Christopher
    Saxena, Sonia
    Chhaya, Vivek
    Cecil, Elizabeth
    Curcin, Vasa
    Pollok, Richard
    [J]. INFLAMMATORY BOWEL DISEASES, 2017, 23 (04) : 672 - 680
  • [2] Effectiveness and safety of ustekinumab induction therapy for 103 patients with ulcerative colitis: a GETAID multicentre real-world cohort study
    Amiot, Aurelien
    Filippi, Jerome
    Abitbol, Vered
    Cadiot, Guillaume
    Laharie, David
    Serrero, Melanie
    Altwegg, Romain
    Bouhnik, Yoram
    Peyrin-Biroulet, Laurent
    Gilletta, Cyrielle
    Roblin, Xavier
    de Chambrun, Guillaume Pineton
    Vuitton, Lucine
    Bourrier, Anne
    Nancey, Stephane
    Gornet, Jean-Marc
    Nahon, Stephane
    Bouguen, Guillaume
    Viennot, Stephanie
    Pariente, Benjamin
    Fumery, Mathurin
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 51 (11) : 1039 - 1046
  • [3] Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease
    Ananthakrishnan, Ashwin N.
    Shi, Hai Yun
    Tang, Whitney
    Law, Cindy C. Y.
    Sung, Joseph J. Y.
    Chan, Francis K. L.
    Ng, Siew C.
    [J]. JOURNAL OF CROHNS & COLITIS, 2016, 10 (10) : 1224 - 1236
  • [4] Inflammatory Bowel Disease in the Elderly Is Associated With Worse Outcomes: A National Study of Hospitalizations
    Ananthakrishnan, Ashwin N.
    McGinley, Emily L.
    Binion, David G.
    [J]. INFLAMMATORY BOWEL DISEASES, 2009, 15 (02) : 182 - 189
  • [5] International variation in medication prescription rates among elderly patients with inflammatory bowel disease
    Benchimol, Eric I.
    Cook, Suzanne F.
    Erichsen, Rune
    Long, Millie D.
    Bernstein, Charles N.
    Wong, Jenna
    Carroll, Charlotte F.
    Froslev, Trine
    Sampson, Tim
    Kappelman, Michael D.
    [J]. JOURNAL OF CROHNS & COLITIS, 2013, 7 (11) : 878 - 889
  • [6] Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis
    Bopanna, Sawan
    Ananthakrishnan, Ashwin N.
    Kedia, Saurabh
    Yajnik, Vijay
    Ahuja, Vineet
    [J]. LANCET GASTROENTEROLOGY & HEPATOLOGY, 2017, 2 (04): : 269 - 276
  • [7] Bosca-Watts MM, 2018, SCAND J GASTROENTERO, V2018, P1
  • [8] Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
    Bourrier, A.
    Carrat, F.
    Colombel, J. -F.
    Bouvier, A. -M.
    Abitbol, V.
    Marteau, P.
    Cosnes, J.
    Simon, T.
    Peyrin-Biroulet, L.
    Beaugerie, L.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2016, 43 (02) : 252 - 261
  • [9] Oral Corticosteroids and the Risk of Serious Infections in Patients With Elderly-Onset Inflammatory Bowel Diseases
    Brassard, Paul
    Bitton, Alain
    Suissa, Alain
    Sinyavskaya, Liliya
    Patenaude, Valerie
    Suissa, Samy
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (11) : 1795 - 1802
  • [10] Short and long-term effectiveness and safety of vedolizumab in inflammatory bowel disease: results from the ENEIDA registry
    Chaparro, Maria
    Garre, Ana
    Ricart, Elena
    Iborra, Marisa
    Mesonero, Francisco
    Vera, Isabel
    Riestra, Sabino
    Garcia-Sanchez, Valle
    Luisa De Castro, M.
    Martin-Cardona, Albert
    Aldeguer, Xavier
    Minguez, Miguel
    Barreiro de-Acosta, Manuel
    Rivero, Montserrat
    Munoz, Fernando
    Andreu, Montserrat
    Bargallo, Ana
    Gonzalez-Munoza, Carlos
    Perez Calle, Jose L.
    Fe Garcia-Sepulcre, Mariana
    Bermejo, Fernando
    Maria Huguet, Jose
    Cabriada, Jose L.
    Gutierrez, Ana
    Manosa, Miriam
    Villoria, Albert
    Carbajo, Ana Y.
    Lorente, Rufo
    Garcia-Lopez, Santiago
    Piqueras, Marta
    Hinojosa, Esther
    Arajol, Claudia
    Sicilia, Beatriz
    Macho Conesa, Ana
    Sainz, Empar
    Almela, Pedro
    Llao, Jordina
    Roncero, Oscar
    Camo, Patricia
    Taxonera, Carlos
    Van Domselaar, Manuel
    Pajares, Ramon
    Legido, Jesus
    Madrigal, Rosa
    Lucendo, Alfredo J.
    Alcain, Guillermo
    Domenech, Eugeni
    Gisbert, Javier P.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2018, 48 (08) : 839 - 851