Association of the human leucocyte antigen region with susceptibility to Parkinson's disease

被引：52

作者：

Saiki, Misuzu ^{[2
]}

Baker, Amie ^{[3
]}

Williams-Gray, Caroline H. ^{[2
]}

Foltynie, Thomas ^{[5
]}

Goodman, Reyna S. ^{[4
]}

Taylor, Craig J. ^{[4
]}

Compston, D. Alastair S. ^{[3
]}

Barker, Roger A. ^{[2
]}

Sawcer, Stephen J. ^{[3
]}

Goris, An ^{[1
,3
]}

机构：

[1] Katholieke Univ Leuven, Lab Neuroimmunol, Sect Expt Neurol, B-3000 Louvain, Belgium

[2] Univ Cambridge, Dept Clin Neurosci, Cambridge Ctr Brain Repair, Cambridge, England

[3] Univ Cambridge, Dept Clin Neurosci, Neurol Unit, Cambridge, England

[4] Addenbrookes Hosp, Tissue Typing Lab, Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England

[5] Neurol Inst, Sobell Dept Motor Neurosci, London, England

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2010年 / 81卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

GENE POLYMORPHISMS; HLA ANTIGENS; RISK;

D O I：

10.1136/jnnp.2008.162883

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective The core pathology of Parkinson's disease (PD) is a loss of the dopaminergic neurons in the nigro-striatal pathway, but this is only part of a more widespread pathological process, the nature of which is unknown. Recent data suggest a possible role for inflammation in this disease process. The Human Leucocyte Antigen (HLA) region is one of the most important genetic susceptibility factors in many immune-mediated diseases but has not been extensively investigated in PD. Methods The authors typed the HLA class II loci HLA-DRB1 and -DQB1 in 528 patients with Parkinson's disease and 3430 controls from the UK. Results The authors observed an association of HLA-DRB1 with susceptibility to Parkinson's disease. In particular, HLA-DRB1*03 was more common in patients compared with controls. Conclusions These data suggest a possible role of the HLA region in susceptibility to Parkinson's disease and as such are consistent with other evidence supporting the role of an inflammatory process in the cellular loss in Parkinson's disease, especially of the nigral dopaminergic neurons.

引用

页码：890 / 891

页数：2

共 19 条

[1] High-density SNP genotyping defines 17 distinct haplotypes of the TNF block in the Caucasian population: Implications for haplotype tagging [J].

Allcock, RJN ;

Windsor, L ;

Gut, IG ;

Kucharzak, R ;

Sobre, L ;

Lechner, D ;

Garnier, JG ;

Baltic, S ;

Christiansen, FT ;

Price, P .

HUMAN MUTATION, 2004, 24 (06) :517-525

[2] Interleukin-10 (IL10) and tumor necrosis factor α (TNF) gene polymorphisms in Parkinson's disease patients [J].

Bialecka, M. ;

Klodowska-Duda, G. ;

Kurzawski, M. ;

Slawek, J. ;

Gorzkowska, A. ;

Opala, G. ;

Bialecki, P. ;

Sagan, L. ;

Drozdzik, M. .

PARKINSONISM & RELATED DISORDERS, 2008, 14 (08) :636-640

[3] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[4] Genome-wide genotyping in Parkinson's disease and neurologically normal controls:: first stage analysis and public release of data [J].

Fung, Hon-Chung ;

Scholz, Sonja ;

Matarin, Mar ;

Simon-Sanchez, Javier ;

Hernandez, Dena ;

Britton, Angela ;

Gibbs, J. Raphael ;

Langefeld, Carl ;

Stiegert, Matt L. ;

Schymick, Jennifer ;

Okun, Michael S. ;

Mandel, Ronald J. ;

Fernandez, Hubert H. ;

Foote, Kelly D. ;

Rodriguez, Ramon L. ;

Peckham, Elizabeth ;

De Vrieze, Fabienne Wavrant ;

Gwinn-Hardy, Katrina ;

Hardy, John A. ;

Singleton, Andrew .

LANCET NEUROLOGY, 2006, 5 (11) :911-916

[5] In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease [J].

Gerhard, A ;

Pavese, N ;

Hotton, G ;

Turkheimer, F ;

Es, M ;

Hammers, A ;

Eggert, K ;

Oertel, W ;

Banati, RB ;

Brooks, DJ .

NEUROBIOLOGY OF DISEASE, 2006, 21 (02) :404-412

[6] Genetic analysis of immunomodulating factors in sporadic Parkinson's disease [J].

Krüger, R ;

Hardt, C ;

Tschentscher, F ;

Jäckel, S ;

Kuhn, W ;

Müller, T ;

Werner, J ;

Woitalla, D ;

Berg, D ;

Kühnl, N ;

Fuchs, GA ;

Santos, EJM ;

Przuntek, H ;

Epplen, JT ;

Schöls, L ;

Riess, O .

JOURNAL OF NEURAL TRANSMISSION, 2000, 107 (05) :553-562

[7] HLA typing and Parkinson's disease [J].

Lampe, JB ;

Gossrau, G ;

Herting, B ;

Kempe, A ;

Sommer, U ;

Füssel, M ;

Weber, M ;

Koch, R ;

Reichmann, H .

EUROPEAN NEUROLOGY, 2003, 50 (02) :64-68

[8]

LEHENY WA, 1983, TISSUE ANTIGENS, V21, P260

[9] HISTOCOMPATIBILITY TYPES IN PARKINSONS-DISEASE [J].

MARTTILA, RJ ;

RINNE, UK ;

TIILIKAINEN, A .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1981, 51 (02) :217-221

[10] Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation [J].

Miklossy, Judith ;

Qing, Hong ;

Guo, Jian-Ping ;

Yu, Sheng ;

Wszolek, Zbigniew K. ;

Calne, Donald ;

McGeer, Edith G. ;

McGeer, Patrick L. .

ACTA NEUROPATHOLOGICA, 2007, 114 (03) :243-254

← 1 2 →