Synthesis of Functionalized Spiroaziridine-oxindoles from 3-Ylideneoxindoles: An Easy Route to 3-(Aminoalkyl)oxindoles

被引：24

作者：

Ammetto, I. ^{[1
]}

Gasperi, T. ^{[2
]}

Loreto, M. Antonietta ^{[1
,3
]}

Migliorini, A. ^{[1
,3
]}

Palmarelli, F. ^{[1
]}

Tardella, P. Antonio ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[2] Univ Roma Tre, Dipartimento Ingn Meccan & Ind, I-00146 Rome, Italy

[3] Univ Roma La Sapienza, Ist Chim Biomol, I-00185 Rome, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 35期

关键词：

Aziridination; Spiro compounds; Nitrogen heterocycles; BIOLOGICAL-ACTIVITIES; GAMMA-BUTYROLACTONES; INHIBITORS; SPIROHETEROCYCLES; (-)-HORSFILINE; AZIRIDINES; DERIVATIVES; FACILE; (-)-SPIROTRYPROSTATIN-B; HETEROCYCLIZATION;

D O I：

10.1002/ejoc.200900891

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel potentially bioactive spiroaziridine-oxindoles have been prepared by treatment of easily accessible 3-ylidene-oxindoles with N-{[(4-nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO(2)Et) in the presence of CaO. These compounds gave new 3-(aminoalkyl)oxindole derivatives through easy and regioselective reductive aziridine ring-opening reactions. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：6189 / 6197

页数：9

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