Fixing the GAP: The role of RhoGAPs in cancer

被引：36

作者：

Kreider-Letterman, Gabriel ^{[1
]}

Carr, Nicole M. ^{[1
]}

Garcia-Mata, Rafael ^{[1
]}

机构：

[1] Univ Toledo, Dept Biol Sci, 2801 W Bancroft St, Toledo, OH 43606 USA

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2022年 / 101卷 / 02期

关键词：

RhoGAPs; Rho GTPases; Cancer; Metastasis; Oncogene; Tumor suppressor; Cytsokeleton; Cell adhesion; cell migration; Cell invasion; GTPASE-ACTIVATING PROTEIN; TUMOR-SUPPRESSOR GENE; MINOR HISTOCOMPATIBILITY ANTIGEN; CELL LUNG-CANCER; HEPATOCELLULAR-CARCINOMA CELLS; PROLIFERATION MARKERS KI67; MESSENGER-RNA EXPRESSION; GENOME-WIDE ASSOCIATION; NEGATIVE BREAST-CANCER; RALA SIGNALING PATHWAY;

D O I：

10.1016/j.ejcb.2022.151209

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins. Rho GTPases are signaling proteins that function as molecular switches and are involved in the regulation of most major cellular processes. Cancer development is often associated with abnormalities in Rho GTPase signaling. Rho GTPase signaling is regulated by two families of proteins, guanine nucleotide-exchange factors (RhoGEFs) and GTPase activating proteins (RhoGAPs), that function upstream of the Rho proteins to regulate their activation and inactivation, respectively. While initial work has focused on the role of RhoGEFs in cancer, the RhoGAP family members are rapidly being established as key regulators of cancer development and progression. The aim of this review is to summarize our advances in understanding the role of RhoGAPs in cancer and to discuss their significance in the development of therapeutics.

引用

页数：31

共 513 条

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