Feasibility of a novel weekday-on/weekend-off oral UFT schedule as postoperative adjuvant chemotherapy for colorectal cancer

被引：26

作者：

Sadahiro, S ^{[1
]}

Ohki, S ^{[1
]}

Yamaguchi, S ^{[1
]}

Takahashi, T ^{[1
]}

Otani, Y ^{[1
]}

Tsukikawa, S ^{[1
]}

Yamamura, T ^{[1
]}

Takemiya, S ^{[1
]}

Nagasaki, H ^{[1
]}

Nishiyama, K ^{[1
]}

Fukushima, T ^{[1
]}

Hiki, Y ^{[1
]}

Yamaguchi, S ^{[1
]}

Kumada, K ^{[1
]}

Shimada, H ^{[1
]}

Mitomi, T ^{[1
]}

Makuuchi, H ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Surg, Kanagawa 2591193, Japan

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 2000年 / 46卷 / 03期

关键词：

UFT; compliance; adjuvant chemotherapy; colorectal cancer;

D O I：

10.1007/s002800000146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: When oral anticancer agents are used for adjuvant chemotherapy of colorectal cancer, compliance and feasibility become issues because of the long treatment time. Appropriate studies of these issues are lacking. We investigated compliance and feasibility during a weekday-on/weekend-off schedule of oral UFT (uracil-tegafur) over a period of I year administered as adjuvant chemntherapy to patients with colorectal cancer. Patients and methods: A UFT dose of 600 mg/day was prescribed according to a weekday-on-weekend-off schedule to 87 patients after potentially curative resection. Compliance was investigated in three ways: physician interview, patient self-report, and chemical analysis of urine. The results were compared with the dose prescribed. Feasibility was evaluated on the basis of two indices: relative performance (RP), which was the ratio of the actual total dose taken to the total dose planned. and individual dose intensity (IDI), which was the ratio of the actual dose taken to the dose planned during a given period. Results: The compliance assessed hy physician interview and by patient self-report conformed well with the prescribed dose, the rate of agreement among the three compliance measures being mon than 94%. Chemical analysis of urine in 38 of the patients revealed that they were actually taking the drug. The RP was 0.72, and the IDI was 0.8. Conclusion: From these results, the feasibility of the weekday-on/weekend-off schedule was judged to be good. It is suggested that the feasibility would be even better if the dose of UFT was set according to body surface area.

引用

页码：180 / 184

页数：5

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