Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents

被引：220
作者：
Altmann, Karl-Heinz [1 ]
Gertsch, Juerg [1 ]
机构：
[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland
来源：
NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 02期
关键词：
RING CLOSING METATHESIS; EPOTHILONE-B ANALOG; III BETA-TUBULIN; BIOSYNTHETIC GENE-CLUSTER; MEDIATED ALDOL REACTIONS; HUMAN TUMOR XENOGRAFTS; LARGE-SCALE SYNTHESIS; I CLINICAL-TRIAL; BIOLOGICAL EVALUATION; MARINE SPONGE;
D O I：
10.1039/b515619j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.
引用
收藏
页码：327 / 357
页数：31
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共 376 条
  • [1] Taxanes: Microtubule and Centrosome Targets, and Cell Cycle Dependent Mechanisms of Action
    Abal, M.
    Andreu, J. M.
    Barasoain, I.
    [J]. CURRENT CANCER DRUG TARGETS, 2003, 3 (03) : 193 - 203
  • [2] (-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1
    Adam, GC
    Vanderwal, CD
    Sorensen, EJ
    Cravatt, BF
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (44) : 5480 - 5484
  • [3] Total synthesis of the microtubule stabilizing antitumor agent laulimalide and some nonnatural analogues:: The power of sharpless' asymmetric epoxidation
    Ahmed, A
    Hoegenauer, EK
    Enev, VAS
    Hanbauer, M
    Kaehlig, H
    Öhler, E
    Mulzer, J
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (08) : 3026 - 3042
  • [4] T-taxol conformation
    Alcaraz, AA
    Mehta, AK
    Johnson, SA
    Snyder, JP
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (08) : 2478 - 2488
  • [5] Hydrolyzable hydrophobic taxanes: synthesis and anti-cancer activities
    Ali, S
    Ahmad, I
    Peters, A
    Masters, G
    Minchey, S
    Janoff, A
    Mayhew, E
    [J]. ANTI-CANCER DRUGS, 2001, 12 (02) : 117 - 128
  • [6] Epothilones: A novel class of non-taxane microtubule-stabilizing agents
    Altaha, R
    Fojo, T
    Reed, E
    Abraham, J
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (19) : 1707 - 1712
  • [7] Epothilone B and its Analogs - A New Family of Anticancer Agents
    Altmann, Karl-Heinz
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (02) : 149 - 158
  • [8] Recent developments in the chemical biology of epothilones
    Altmann, KH
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (13) : 1595 - 1613
  • [9] Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity
    Altmann, KH
    Wartmann, M
    O'Reilly, T
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2000, 1470 (03): : M79 - M91
  • [10] The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones
    Altmann, KH
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (15) : 2137 - 2152
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