Host-guest binding in water, salty water, and biofluids: general lessons for synthetic, bio-targeted molecular recognition

被引：78

作者：

Beatty, Meagan A. ^{[1
]}

Hof, Fraser ^{[1
]}

机构：

[1] Univ Victoria, Dept Chem, 3800 Finnerty Rd, Victoria, BC V8W 3V6, Canada

来源：

CHEMICAL SOCIETY REVIEWS | 2021年 / 50卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ENCAPSULATION; CHEMOTHERAPY; CALABADION; SUGAMMADEX; COMPLEXES; REVERSE; CANCER; SENSOR; DRUGS;

D O I：

10.1039/d0cs00495b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic molecular recognition systems are increasingly being used to solve applied problems in the life sciences, and bio-targeted host-guest chemistry has rapidly arisen as a major field of fundamental research. This tutorial review presents a set of fundamental lessons on how host-guest molecular recognition can be programmed in water. The review uses informative examples of aqueous host-guest chemistry organized around generalizable themes and lessons, building towards lessons focused on molecular recognition in salty solutions and biological fluids. It includes selected examples of macrocyclic host systems that work well, as well as common pitfalls and how to avoid them. The review closes with a survey of the most important and inspirational recent advances, which involve host-guest chemistry in living cells and organisms.

引用

页码：4812 / 4832

页数：21

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