Nanoparticles for super-resolution microscopy and single-molecule tracking

被引：234

作者：

Jin, Dayong ^{[1
]}

Xi, Peng ^{[2
]}

Wang, Baoming ^{[1
]}

Zhang, Le ^{[1
]}

Enderlein, Joerg ^{[3
]}

van Oijen, Antoine M. ^{[4
,5
]}

机构：

[1] Univ Technol Sydney, IBMD, Fac Sci, Ultimo, NSW, Australia

[2] Peking Univ, Coll Engn, Dept Biomed Engn, Beijing, Peoples R China

[3] Univ Gottingen, Inst Phys 3, Gottingen, Germany

[4] Univ Wollongong, Sch Chem, Wollongong, NSW, Australia

[5] Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia

来源：

NATURE METHODS | 2018年 / 15卷 / 06期

基金：

中国国家自然科学基金; 澳大利亚研究理事会;

关键词：

UP-CONVERSION NANOPARTICLES; STIMULATED-EMISSION DEPLETION; NITROGEN-VACANCY CENTERS; DOPED UPCONVERTING NANOPARTICLES; SEMICONDUCTING POLYMER DOTS; QUANTUM DOTS; LIVING CELLS; CARBON DOTS; STED NANOSCOPY; FLUORESCENT NANODIAMONDS;

D O I：

10.1038/s41592-018-0012-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We review the use of luminescent nanoparticles in super-resolution imaging and single-molecule tracking, and showcase novel approaches to super-resolution imaging that leverage the brightness, stability, and unique optical-switching properties of these nanoparticles. We also discuss the challenges associated with their use in biological systems, including intracellular delivery and molecular targeting. In doing so, we hope to provide practical guidance for biologists and continue to bridge the fields of super-resolution imaging and nanoparticle engineering to support their mutual advancement.

引用

页码：415 / 423

页数：9

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