RETRACTED: Role of microRNAs in diagnosis and treatment of the pathogenesis of gastric cancer (Retracted article. See vol. 8, pg. 11862, 2015)

被引：1
作者：
Chen, Gang [1 ]
Tang, Yong [1 ]
Wu, Jiang-Hua [2 ]
Liu, Feng-Hua [2 ]
机构：
[1] Wuhan Univ, Zhongnan Hosp, Dept Radiat & Med Oncol, Wuhan 430072, Peoples R China
[2] Tianjin Med Univ, Canc Inst & Hosp, Dept Gynecol Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 12期
关键词：
microRNAs; gastric cancer; SGC-7901; diagnosis biomarker; CELL-PROLIFERATION; EXPRESSION; PATHWAY; OVEREXPRESSION; TUMORIGENESIS; CONTRIBUTES; POPULATION; BIOMARKERS; MOTILITY; INVASION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We aim to detect the miRNAs that are correlated with the gastric cancer cell line SGC-7901 to provide theoretical basis for clinical application. We first analyzed miRNA expression profiles of gastric cancer patients compared with normal controls by microarray analysis and validated the results by real-time qPCR. We also determined the absolute copy numbers of these three miRNAs in normal adults. The results showed that three miRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 gastric cancer patients compared with 90 normal controls. Molecular and statistical analysis showed that the decreased miRNAs were significant in clinical analysis. Generally speaking, this finding suggest vital roles of these miRNAs in human gastric cancer genesis and as potential biomarkers in gastric cancer diagnosis.
引用
收藏
页码：5947 / 5957
页数：11
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