TCR+ CD3+ CD4- CD8- effector T cells in psoriasis

被引：52

作者：

Brandt, D. ^{[1
]}

Sergon, M. ^{[2
]}

Abraham, S. ^{[3
]}

Maebert, K. ^{[1
]}

Hedrich, C. M. ^{[1
,4
,5
]}

机构：

[1] Tech Univ Dresden, Fac Med Carl Gustav Carus, Childrens Hosp Dresden, Div Pediat Rheumatol & Immunol, Dresden, Germany

[2] Tech Univ Dresden, Fac Med Carl Gustav Carus, Inst Pathol, Dresden, Germany

[3] Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Dermatol, Dresden, Germany

[4] Univ Liverpool, Inst Translat Med, Dept Womens & Childrens Hlth, Liverpool, Merseyside, England

[5] Alder Hey Childrens NHS Fdn Trust Hosp, Dept Paediat Rheumatol, Liverpool, Merseyside, England

来源：

CLINICAL IMMUNOLOGY | 2017年 / 181卷

关键词：

Psoriasis; Programmed death-1; PD-1; Double negative T cells; IFN-gamma; Effector memory T cells; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTERFERON-GAMMA; IFN-GAMMA; ALPHA; PD-1; EXPRESSION; SKIN; RECEPTOR; IDENTIFICATION; LYMPHOCYTE;

D O I：

10.1016/j.clim.2017.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The autoimmune/inflammatory disorder psoriasis is characterized by keratinocyte proliferation and immune cell infiltration of the skin. TCR+ CD3(+) CD4(-) CDS- "double negative" (DN) T cells can derive from CD8(+) T cells through the down-regulation of CD8. The inhibitory molecule programmed death (PD-)1 is expressed on activated T cells and plays a role in the maintenance of peripheral tolerance. A subset of DN T cells, characterized by the expression of PD-1, has recently been demonstrated to be self-reactive. We demonstrate that a majority of DN T cells exhibits effector memory phenotypes, express IFN-gamma, and fail to proliferate. DN T cells from psoriasis patients are characterized by reduced DNA methylation of the IFNG gene and increased PD-1 expression. Furthermore, PD-1 positive DN T cells infiltrate the epidermis in psoriatic skin lesions. Our observations offer additional insight into the molecular pathophysiology of plaque psoriasis and show promise as potential disease biomarkers and/or therapeutic targets for future interventions. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：51 / 59

页数：9

共 63 条

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