Diagnostic tests are used in a wide range of behavioral, medical, psychosocial, and healthcare-related research. Test sensitivity and specificity are the most popular measures of accuracy for diagnostic tests. Available methods for analyzing longitudinal study designs assume fixed gold or reference standards and as such do not apply to studies with dynamically changing reference standards, which are especially popular in psychosocial research. In this article, we develop a novel approach to address missing data and other related issues for modeling sensitivity and specificity within such a time-varying reference standard setting. The approach is illustrated with real as well as simulated data.
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Cornell Univ, Hosp Special Surg, Dept Publ Hlth, Weill Med Coll, New York, NY 10021 USACornell Univ, Hosp Special Surg, Dept Publ Hlth, Weill Med Coll, New York, NY 10021 USA
Yan, Ma
Alejandro, Gonzalez Della Valle
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Hosp Special Surg, Dept Orthoped, New York, NY 10021 USACornell Univ, Hosp Special Surg, Dept Publ Hlth, Weill Med Coll, New York, NY 10021 USA
Alejandro, Gonzalez Della Valle
Hui, Zhang
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Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY 14642 USACornell Univ, Hosp Special Surg, Dept Publ Hlth, Weill Med Coll, New York, NY 10021 USA
Hui, Zhang
Tu, X. M.
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Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY 14642 USA
Univ Rochester, Dept Psychiat, Rochester, NY 14642 USACornell Univ, Hosp Special Surg, Dept Publ Hlth, Weill Med Coll, New York, NY 10021 USA
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Seoul Natl Univ, Inst Construct & Environm Engn, Seoul 08826, South KoreaSeoul Natl Univ, Inst Construct & Environm Engn, Seoul 08826, South Korea
Kim, Heegang
Kim, Jihye
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Kwangwoon Univ, Coll Engn, Dept Architectural Engn, Seoul 01897, South KoreaSeoul Natl Univ, Inst Construct & Environm Engn, Seoul 08826, South Korea
Kim, Jihye
Yeo, Myoungsouk
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Seoul Natl Univ, Inst Construct & Environm Engn, Seoul 08826, South Korea
Seoul Natl Univ, Coll Engn, Dept Architecture & Architectural Engn, Seoul 08826, South KoreaSeoul Natl Univ, Inst Construct & Environm Engn, Seoul 08826, South Korea