Platelet-Rich Plasma (PRP) Promotes Survival of Fat-Grafts in Rats

被引：107

作者：

Nakamura, Shinichiro ^{[1
]}

Ishihara, Masayuki ^{[2
]}

Takikawa, Megumi ^{[1
]}

Murakami, Kaoru ^{[2
]}

Kishimoto, Satoko ^{[2
]}

Nakamura, Shingo ^{[2
]}

Yanagibayashi, Satoshi ^{[1
]}

Kubo, Satoshi ^{[1
]}

Yamamoto, Naoto ^{[1
]}

Kiyosawa, Tomoharu ^{[1
]}

机构：

[1] Natl Def Med Coll, Dept Plast & Reconstruct Surg, Tokorozawa, Saitama 3598513, Japan

[2] Natl Def Med Coll, Div Biomed Engn, Tokorozawa, Saitama 3598513, Japan

来源：

ANNALS OF PLASTIC SURGERY | 2010年 / 65卷 / 01期

关键词：

PRP; fat-graft; FIBROBLAST-GROWTH-FACTOR; AUTOLOGOUS FAT; TRANSPLANTATION; INJECTION; BIOACTIVATION; AUGMENTATION; TRANSFERS; SURGERY; WOUNDS; GEL;

D O I：

10.1097/SAP.0b013e3181b0273c

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This study evaluated the effects of platelet-rich plasma (PRP) on resorption and adipocyte survival in autologous fat-graft of rats prepared with isogenous PRP. Fat grafts prepared without PRP (control group) became united to the tissue adjacent to the implantation site and were significantly resorbed from 30 days. On the other hand, fat grafts prepared with PRP (PRP group) demonstrated little resorption from 30 to 120 days and appeared pink, had a soft, supple feel, and were easily compressible. Histologic sections of grafts in the control and PRP groups at 10 days exhibited similar consolidation of the grafted tissue, which contained morphologically normal adipocytes with different degrees of granulation and capillary formation. From 20 days normal adipocytes were obviously decreased in the control group, while the PRP group demonstrated increased granulation tissue and capillary formation and good maintenance of normal adipocytes for at least 120 days.

引用

页码：101 / 106

页数：6

共 26 条

[1]

Abuzeni P., 2001, AM J COSMETIC SURG, V18, P59, DOI [10.1177/074880680101800202, DOI 10.1177/074880680101800202]

[2] HISTORICAL REVIEW AND PRESENT STATUS OF FREE FAT GRAFT AUTO-TRANSPLANTATION IN PLASTIC AND RECONSTRUCTIVE SURGERY [J].

BILLINGS, E ;

MAY, JW .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1989, 83 (02) :368-381

[3] AUTOLOGOUS FAT TRANSPLANTATION EMPLOYING LIPOSUCTION TECHNIQUES [J].

BIRCOLL, M ;

NOVACK, BH .

ANNALS OF PLASTIC SURGERY, 1987, 18 (04) :327-329

[4] COMPARATIVE EXPERIMENTAL-STUDY OF AUTOLOGOUS ADIPOSE-TISSUE PROCESSED BY DIFFERENT TECHNIQUES [J].

CHAJCHIR, A ;

BENZAQUEN, I ;

MORETTI, E .

AESTHETIC PLASTIC SURGERY, 1993, 17 (02) :113-115

[5] FAT INJECTION [J].

CHAJCHIR, A ;

BENZAQUEN, I ;

WEXLER, E ;

ARELLANO, A .

AESTHETIC PLASTIC SURGERY, 1990, 14 (02) :127-136

[6]

CHAJCHIR A, 1989, PLAST RECONSTR SURG, V84, P921, DOI 10.1097/00006534-198912000-00009

[7] FREE AUTOGENOUS PEARL FAT GRAFTS IN THE FACE - A PRELIMINARY-REPORT OF A REDISCOVERED TECHNIQUE [J].

ELLENBOGEN, R .

ANNALS OF PLASTIC SURGERY, 1986, 16 (03) :179-194

[8] A PHYSICOCHEMICAL APPROACH TO IMPROVING FREE FAT GRAFT-SURVIVAL - PRELIMINARY-OBSERVATIONS [J].

EPPLEY, BL ;

SADOVE, AM .

AESTHETIC PLASTIC SURGERY, 1991, 15 (03) :215-218

[9] BIOACTIVATION OF FREE-FAT TRANSFERS - A POTENTIAL NEW APPROACH TO IMPROVING GRAFT-SURVIVAL [J].

EPPLEY, BL ;

SIDNER, RA ;

PLATIS, JM ;

SADOVE, AM .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1992, 90 (06) :1022-1030

[10] AUTOLOGOUS FACIAL FAT TRANSPLANTATION - IMPROVED GRAFT MAINTENANCE BY MICROBEAD BIOACTIVATION [J].

EPPLEY, BL ;

SNYDERS, RV ;

WINKELMANN, T ;

DELFINO, JJ .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1992, 50 (05) :477-482

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