DNA with hydrophobic base substitutes: A stable, zipperlike recognition motif based on interstrand-stacking interactions

被引：83

作者：

Brotschi, C ^{[1
]}

Leumann, CJ ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 14期

关键词：

biaryls; bioorganic chemistry; DNA recognition; hydrophobic effect; nucleosides;

D O I：

10.1002/anie.200250516

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Back to basis: Short DNA duplexes can be packed with at least four hydrophobic, not-hydrogen-bonding biphenyl base pairs in the center of the sequence without compromising stability. Recognition of Bph occurrs by interstrand-stacking interactions as illustrated (X=biphenyl or bipyridyl). This new zipperlike recognition motif opens exciting possibilities for the introduction of new function into double-helical recognition systems based on the DNA backbone.

引用

页码：1655 / 1658

页数：4

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