This study reports on the use of the tailored design method (TDM) for survey response in two separate studies (i.e. the Retrospective Study and the TIP #24 Study). Both studies used similar procedures to design and collect the data, but yielded vastly different response rates. Examination of these studies revealed factors that may have influenced the response rates beyond the pproscriptions described by the TDM. Six factors that may have influenced non-response were: (1) the extent of participants' interest in the study, (2) the degree the researchers had a comprehensive understanding of the participants, (3) the characteristics of the mailing lists obtained, (4) selection criteria from that list, (5) types of incentives used, and (6) name recognition of the study sponsor. This study provides researchers with lessons for future mailed surveys. Published by Elsevier Science Ltd.