Evaluation of the effect of intranasal infiltrated botulinum toxin-A on a model of allergic rhinitis in rabbits: An Experimental Study

被引：6

作者：

Gunes, Murat Salih ^{[1
]}

Kulahli, Ismail ^{[2
]}

Kokoglu, Kerem ^{[2
]}

Vural, Alperen ^{[2
]}

Avci, Deniz ^{[2
]}

Gulec, Safak ^{[3
]}

Sonmez, Mehmet Fatih ^{[4
]}

Cilenk, Kubra Tugba ^{[4
]}

Ercal, Baris Derya ^{[5
]}

机构：

[1] Kayseri Training & Res Hosp, Dept Otolaryngol Head & Neck Surg, Kayseri, Turkey

[2] Erciyes Univ, Dept Otolaryngol Head & Neck Surg, Fac Med, Kayseri, Turkey

[3] Special Neon Hosp, Dept Otolaryngol Head & Neck Surg, Erzincan, Turkey

[4] Erciyes Univ, Dept Histol & Embryol, Fac Med, Kayseri, Turkey

[5] Erciyes Univ, Dept Med Microbiol, Fac Med, Kayseri, Turkey

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2016年 / 83卷 / 04期

关键词：

Acetylcholine; Eosinophils; Immunotherapy; Turbinates; Metaplasia; FREY-SYNDROME; NASAL-MUCOSA; INJECTION; ASTHMA; MEDICINE; SYMPTOMS; UPDATE; IMPACT; RATS;

D O I：

10.1016/j.ijporl.2016.01.010

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Introduction: Allergic Rhinitis (AR) effects 20-40% of the global population and its prevalance increases. Medical treatment and immunotherapy could be used in AR management. But they are not definitive solution. Medical treatment must be used a long time and has side effects. Immunotherapy cannot be applied to every patient and it also takes a long time. The aim of this study is to evaluate symptomatic and histopathological effects of intranasal infiltrated Botulinum Toxin-A (Btx-A) on an animal model of AR. Material-Method: 15 rabbits were divided into 3 groups as control, disease and treatment. AR was formed in disease and treatment groups by intraperitoneal and intranasal ovalbumine. Allergic symptoms were observed and serum IgE levels were estimated to prove forming of AR. Btx-A was infiltrated in inferior turbinates of rabbits in treatment group. Rabbits were sacrified on 32nd day. Paranasal structures were disected and investigated histopathologically. Results: Serous nasal discharge and sneezing were observed after ovalbumine applying in disease and treatment groups. Serum IgE levels on 21st day were higher than 1st day and this difference was significant statistically in disease and treatment groups. Serous discharge and sneezing decreased after Btx-A infiltration in treatment group. In histopathological examination, there were significant difference between disease and treatment group in terms of some histopathological findings. Conclusion: Considering the effect of Btx-A on AR in animal, it can be said that Btx-A can decrease symptoms and reorganize histopathological findings of AR. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 56

页数：6

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