S100A6 protein: functional roles

被引：108
作者：
Donato, Rosario [1 ,2 ]
Sorci, Guglielmo [1 ,2 ]
Giambanco, Ileana [1 ]
机构：
[1] Univ Perugia, Dept Expt Med, Ctr Univ Ric Genom Funz, Perugia Med Sch, Piazza Lucio Severi 1, I-06132 Perugia, Italy
[2] Univ Perugia, Dept Expt Med, Interuniv Inst Myol, Ist Interuniv Miol,Perugia Med Sch, Piazza Lucio Severi 1, I-06132 Perugia, Italy
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 15期
关键词：
S100A6; protein; Proliferation; Migration/motility; Cancer; Invasion; Cytoskeleton; Receptor; CALCIUM-BINDING PROTEINS; CELL-CYCLE PROGRESSION; CALCYCLIN S100A6; GROWTH-FACTOR; UP-REGULATION; MOLECULAR-CLONING; GENE-EXPRESSION; S-100; PROTEIN; INTERMEDIATE-FILAMENTS; MYOCARDIAL-INFARCTION;
D O I：
10.1007/s00018-017-2526-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
S100A6 protein belongs to the A group of the S100 protein family of Ca2+-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin beta 1 transduce some extracellular S100A6's effects. Dosage of serum S100A6 might aid in diagnosis in oncology.
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收藏
页码：2749 / 2760
页数：12
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