Aptamer Turn-On SERS/RRS/Fluorescence Tri-mode Platform for Ultra-trace Urea Determination Using Fe/N-Doped Carbon Dots

被引：10
作者：
Li, Chongning [1 ,2 ,3 ]
Li, Jiao [1 ,2 ,3 ]
Liang, Aihui [1 ,2 ,3 ]
Wen, Guiqing [1 ,2 ,3 ]
Jiang, Zhiliang [1 ,2 ,3 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China
[2] Guangxi Normal Univ, Minist Educ, Key Lab Ecol Rare & Endangered Species & Environm, Guilin, Peoples R China
[3] Guangxi Key Lab Environm Pollut Control Theory &, Guilin, Peoples R China
来源：
FRONTIERS IN CHEMISTRY | 2021年 / 9卷
基金：
中国国家自然科学基金;
关键词：
Fe; N-doped carbon dots; catalysis amplification; aptamer; surface-enhanced Raman scattering; resonance Rayleigh scattering; fluorescence; PEROXIDASE-LIKE ACTIVITY; QUANTITATIVE-ANALYSIS; GRAPHENE; FLUORESCENCE; SERS; NANOPARTICLES; PERFORMANCE; REDUCTION; NITROGEN; SENSOR;
D O I：
10.3389/fchem.2021.613083
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sensitive and selective methods for the determination of urea in samples such as dairy products are important for quality control and health applications. Using ammonium ferric citrate as a precursor, Fe/N-codoped carbon dots (CDFeN) were prepared by a hydrothermal procedure and characterized in detail. CDFeN strongly catalyzes the oxidation of 3,3 ',5,5 '-tetramethylbenzidine (TMB) by H2O2 to turn on an indicator molecular reaction, forming an oxidized tetramethylbenzidine (TMBox) probe with surface-enhanced Raman scattering, resonance Rayleigh scattering, and fluorescence (SERS, RRS, and FL) signals at 1,598 cm(-1), 370 nm, and 405 nm, respectively. The urea aptamer (Apt) can turn off the indicator reaction to reduce the tri-signals, and the addition of urea turns on the indicator reaction to linearly enhance the SERS/RRS/FL intensity. Thus, a novel Apt turn-on tri-mode method was developed for the assay determination of ultra-trace urea with high sensitivity, good selectivity, and accuracy. Trace adenosine triphosphate and estradiol can also be determined by the Apt-CDFeN catalytic analytical platform.
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页数：11
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