Synthesis of novel fused tricyclic quinolones:: 4α,5-dihydro-1H-[1,2,4]triazino[1,6-α]quinoline-2,4,6(3H)-triones

被引：2

作者：

Edmont, D ^{[1
]}

Marot, C ^{[1
]}

Chenault, J ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, F-45067 Orleans 2, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2002年 / 39卷 / 06期

关键词：

D O I：

10.1002/jhet.5570390608

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile methodology to build the 1H-[1,2,4]triazino[1,6-a]quinoline-2,4,6(3H)-trione structure from methyl 6-fluoro4-oxo-1,4-dihydro-2-quinolinecarboxylate was developed. The method involves an N-amination followed by condensation of an aroyl isocyanate to form an alpha semicarbazidocarboxylate that readily cyclizes to the fused [1,2,4]triazino ring under ammonia/ethanol condition. Also, the reactivity of the [1,2,4]triazino ring thus obtained was studied.

引用

页码：1161 / 1165

页数：5

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