gamma-H2AX: Can it be established as a classical cancer prognostic factor?

被引：74
作者：
Palla, Viktoria-Varvara [1 ]
Karaolanis, Georgios [2 ]
Katafigiotis, Ioannis [3 ]
Anastasiou, Ioannis [3 ]
Patapis, Paul [4 ]
Dimitroulis, Dimitrios [5 ]
Perrea, Despoina [5 ]
机构：
[1] Diakonie Klinikum Schwabisch Hall, Dept Obstet & Gynecol, Schwabisch Hall, Germany
[2] Laikon Gen Hosp, Med Sch Athens, Dept Surg 1, Vasc Unit, Athens, Greece
[3] Univ Athens, Laiko Hosp, Univ Urol Clin 1, Athens, Greece
[4] Univ Athens, Attikon Gen Hosp, Dept Surg 3, Athens, Greece
[5] Univ Athens, Laiko Hosp, Dept Surg 2, Athens, Greece
来源：
TUMOR BIOLOGY | 2017年 / 39卷 / 03期
关键词：
gamma-H2AX; cancer; prognosis; histone; DNA damage; DOUBLE-STRAND BREAKS; PHOSPHORYLATED HISTONE H2AX; DNA-DAMAGE; GENOMIC INSTABILITY; POOR-PROGNOSIS; UV-IRRADIATION; IN-VIVO; EXPRESSION; REPAIR; MARKER;
D O I：
10.1177/1010428317695931
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double-strand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.
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页码：1 / 11
页数：11
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