The Role of High Mobility Group Box-1 in Epileptogenesis

被引：1

作者：

Fu, Li ^{[1
]}

Nishibori, Masahiro ^{[1
]}

机构：

[1] Okayama Univ, Dept Pharmacol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

来源：

ACTA MEDICA OKAYAMA | 2019年 / 73卷 / 05期

关键词：

HMGB1; epileptogenesis; inflammation; blood-brain barrier; TOLL-LIKE RECEPTOR; MONOCLONAL-ANTIBODY; HMGB1; EPILEPSY; PROTEIN; DYSFUNCTION; BIOMARKERS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.

引用

页码：383 / 386

页数：4

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