Synthesis and biological activity of fluorine-containing amino derivatives based on 4-caranethiol

被引：11
|
作者：
Sudarikov, D. V. [1 ]
Krymskaya, Yu. V. [1 ]
Il'chenko, N. O. [1 ]
Slepukhin, P. A. [2 ,3 ]
Rubtsova, S. A. [1 ]
Kutchin, A. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Chem, Komi Sci Ctr, Ural Branch, 48 Ul Pervomaiskaya, Syktyvkar 167982, Russia
[2] Russian Acad Sci, I Ya Postovsky Inst Organ Synth, Ural Branch, 22-20 Ul S Kovalevskoy Akad Skaya, Ekaterinburg 620990, Russia
[3] Ural Fed Univ, 19 Ul Mira, Ekaterinburg 620002, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2018年 / 67卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
4-caranethiol; sulfenimines; sulfinimines; chiral fluorine-containing N-substituted alpha-branched sulfinamides; Ruppert-Prakash reagent; fluorine-containing Reformatsky reagent; antimicrobial activity; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; TERT-BUTANESULFINIMINES; MEDICINAL CHEMISTRY; CHIRAL AUXILIARY; BETA-PEPTIDES; ACIDS; SULFINIMINES; IMINES; TRIFLUOROPYRUVATE;
D O I：
10.1007/s11172-018-2130-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fluorine-containing N-substituted sulfinamides were synthesized via 4-caranethiol-based sulfenimines and sulfinimines. Stereochemical features of oxidation of sulfenimines and addition of fluorine-containing reagents to sulfinimines were discussed. Antimicrobial activities of the obtained compounds were screened.
引用
收藏
页码：731 / 742
页数：12
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