Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy

被引：43
|
作者：
Kong, Ming [1 ]
Hou, Lin [1 ]
Wang, Juan [1 ]
Feng, Chao [1 ]
Liu, Ya [1 ]
Cheng, Xiaojie [1 ]
Chen, Xiguang [1 ]
机构：
[1] Ocean Univ China, Biochem & Biomat Fey Lab Shandong Coll & Univ, Coll Marine Life Sci, Qingdao, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 08期
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
NANOCARRIER; CARRIER; ART;
D O I：
10.1039/c4cc08746a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel hyaluronic acid modified transfersome was prepared to deliver drugs to lymphatics through the transdermal route. Doxorubicin loaded HA-GMS-T was able to efficiently penetrate into the deep skin tissue, leading to enhanced absorption by lymphatics. Most importantly, hyaluronic acid effectively improved the uptake of drug loaded nanocarriers by tumor cells.
引用
收藏
页码：1453 / 1456
页数：4
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