Estimating and testing bioconcentration factors

被引：6

作者：

Bailer, AJ ^{[1
]}

Walker, SE

Venis, KJ

机构：

[1] Miami Univ, Dept Math & Stat, Oxford, OH 45056 USA

[2] Miami Univ, Ctr Environm Toxicol & Stat, Dept Zool, Oxford, OH 45056 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2000年 / 19卷 / 09期

关键词：

uptake-elimination experiments; nonlinear regression; delta method; standard errors; confidence intervals;

D O I：

10.1002/etc.5620190925

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bioconcentration factors (BCFs) are commonly calculated to represent the equilibrium concentration of a substance in an organism relative to environmental concentrations of the same substance. The BCF is derived from parameters estimated in uptake and elimination experiments and is presented as a single value without error estimates or confidence intervals. However, it is desirable to know the variability/precision of the BCF estimate and to statistically compare BCFs among experimental conditions. In this study, the calculation of standard errors and confidence intervals for BCFs is presented. In addition, a statistical method for formally comparing the BCFs derived under two or more experimental conditions is discussed. These methods are illustrated using data from a study of DDT-exposed Hyalella azteca and Diporeia spp.

引用

页码：2338 / 2340

页数：3