Estimating and testing bioconcentration factors

被引：6

作者：

Bailer, AJ ^{[1
]}

Walker, SE

Venis, KJ

机构：

[1] Miami Univ, Dept Math & Stat, Oxford, OH 45056 USA

[2] Miami Univ, Ctr Environm Toxicol & Stat, Dept Zool, Oxford, OH 45056 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2000年 / 19卷 / 09期

关键词：

uptake-elimination experiments; nonlinear regression; delta method; standard errors; confidence intervals;

D O I：

10.1002/etc.5620190925

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bioconcentration factors (BCFs) are commonly calculated to represent the equilibrium concentration of a substance in an organism relative to environmental concentrations of the same substance. The BCF is derived from parameters estimated in uptake and elimination experiments and is presented as a single value without error estimates or confidence intervals. However, it is desirable to know the variability/precision of the BCF estimate and to statistically compare BCFs among experimental conditions. In this study, the calculation of standard errors and confidence intervals for BCFs is presented. In addition, a statistical method for formally comparing the BCFs derived under two or more experimental conditions is discussed. These methods are illustrated using data from a study of DDT-exposed Hyalella azteca and Diporeia spp.

引用

页码：2338 / 2340

页数：3

共 11 条

[1] Agresti A., 1990, Analysis of categorical data
[2] ARNOLD S, 1990, MATH SCI
[3] Lotufo GR, 2000, ENVIRON TOXICOL CHEM, V19, P368, DOI [10.1002/etc.5620190217, 10.1897/1551-5028(2000)019&lt
[4] 0368:CTATOD&gt
[5] 2.3.CO
[6] 2]
[7] Morgan B. J. T., 1992, ANAL QUANTAL RESPONS
[8] Newman M. C., 1995, QUANTITATIVE METHODS
[9] Rand, 1995, FUNDAMENTALS AQUATIC, P703
[10] Rand G.M., 1995, Fundamentals of aquatic toxicology effects, environmental fate, and risk assessment, P3

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