A Proteome-Scale Map of the Human Interactome Network

被引:985
作者
Rolland, Thomas [1 ,2 ,3 ]
Tasan, Murat [1 ,2 ,4 ,5 ,6 ,7 ]
Charloteaux, Benoit [1 ,2 ,3 ]
Pevzner, Samuel J. [1 ,2 ,3 ,8 ,9 ]
Zhong, Quan [1 ,2 ,3 ,10 ]
Sahni, Nidhi [1 ,2 ,3 ]
Yi, Song [1 ,2 ,3 ]
Lemmens, Irma [11 ]
Fontanillo, Celia [12 ,13 ]
Mosca, Roberto [14 ]
Kamburov, Atanas [1 ,2 ,3 ]
Ghiassian, Susan D. [1 ,2 ]
Yang, Xinping [1 ,2 ,3 ]
Ghamsari, Lila [1 ,2 ,3 ]
Balcha, Dawit [1 ,2 ,3 ]
Begg, Bridget E. [1 ,2 ,3 ]
Braun, Pascal [1 ,2 ,3 ]
Brehme, Marc [1 ,2 ,3 ]
Broly, Martin P. [1 ,2 ,3 ]
Carvunis, Anne-Ruxandra [1 ,2 ,3 ]
Convery-Zupan, Dan [1 ,2 ,3 ]
Corominas, Roser [17 ]
Coulombe-Huntington, Jasmin [1 ,2 ,18 ]
Dann, Elizabeth [1 ,2 ,3 ]
Dreze, Matija [1 ,2 ,3 ]
Dricot, Amelie [1 ,2 ,3 ]
Fan, Changyu [1 ,2 ,3 ]
Franzosa, Eric [1 ,2 ,18 ]
Gebreab, Fana [1 ,2 ,3 ]
Gutierrez, Bryan J. [1 ,2 ,3 ]
Hardy, Madeleine F. [1 ,2 ,3 ]
Jin, Mike [1 ,2 ,3 ]
Kang, Shuli [17 ]
Kiros, Ruth [1 ,2 ,3 ]
Lin, Guan Ning [3 ,17 ]
Luck, Katja [1 ,2 ,3 ]
MacWilliams, Andrew [1 ,2 ,3 ]
Menche, Joerg [1 ,2 ,15 ,16 ]
Murray, Ryan R. [1 ,2 ,3 ]
Palagi, Alexandre [1 ,2 ,3 ]
Poulin, Matthew M. [1 ,2 ,3 ]
Rambout, Xavier [1 ,2 ,3 ,19 ]
Rasla, John [1 ,2 ,3 ]
Reichert, Patrick [1 ,2 ,3 ]
Romero, Viviana [1 ,2 ,3 ]
Ruyssinck, Elien [11 ]
Sahalie, Julie M. [1 ,2 ,3 ]
Scholz, Annemarie [1 ,2 ,3 ]
Shah, Akash A. [1 ,2 ,3 ]
Sharma, Amitabh [1 ,2 ,15 ,16 ]
机构
[1] Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA
[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
[3] Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA
[4] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada
[5] Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada
[6] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada
[7] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada
[8] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[9] Boston Univ, Sch Med, Boston, MA 02118 USA
[10] Wright State Univ, Dept Biol Sci, Dayton, OH 45435 USA
[11] VIB, Dept Med Prot Res, B-9000 Ghent, Belgium
[12] Univ Salamanca, Canc Res Ctr, E-37008 Salamanca, Spain
[13] CSIC, Salamanca 37008, Spain
[14] Inst Res Biomed IRB Barcelona, Joint IRB BSC Program Computat Biol, Barcelona 08028, Spain
[15] Northeastern Univ, CCNR, Boston, MA 02115 USA
[16] Northeastern Univ, Dept Phys, Boston, MA 02115 USA
[17] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[18] McGill Univ, Dept Bioengn, Montreal, PQ H3A 0C3, Canada
[19] Univ Liege, GIGA R, Prot Signaling & Interact Lab, B-4000 Liege, Belgium
[20] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[21] ICREA, Barcelona 08010, Spain
[22] Canadian Inst Adv Res, Toronto, ON M5G 1Z8, Canada
基金
美国国家科学基金会; 加拿大自然科学与工程研究理事会;
关键词
MOLECULAR INTERACTION DATABASE; GENOME-WIDE ASSOCIATION; POSTTRANSLATIONAL MODIFICATIONS; COMPREHENSIVE RESOURCE; GENE; EXPRESSION; CENSUS; DRAFT; LOCI;
D O I
10.1016/j.cell.2014.10.050
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand geno-type- phenotype relationships. Here, we describe a systematic map of similar to 14,000 high-quality human binary protein-protein interactions. At equal quality, this map is similar to 30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a "broader'' human interactome network than currently appreciated. The map also uncovers significant inter-connectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots'' of the genomic revolution.
引用
收藏
页码:1212 / 1226
页数:15
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