A Proteome-Scale Map of the Human Interactome Network

被引：985

作者：

Rolland, Thomas ^{[1
,2
,3
]}

Tasan, Murat ^{[1
,2
,4
,5
,6
,7
]}

Charloteaux, Benoit ^{[1
,2
,3
]}

Pevzner, Samuel J. ^{[1
,2
,3
,8
,9
]}

Zhong, Quan ^{[1
,2
,3
,10
]}

Sahni, Nidhi ^{[1
,2
,3
]}

Yi, Song ^{[1
,2
,3
]}

Lemmens, Irma ^{[11
]}

Fontanillo, Celia ^{[12
,13
]}

Mosca, Roberto ^{[14
]}

Kamburov, Atanas ^{[1
,2
,3
]}

Ghiassian, Susan D. ^{[1
,2
]}

Yang, Xinping ^{[1
,2
,3
]}

Ghamsari, Lila ^{[1
,2
,3
]}

Balcha, Dawit ^{[1
,2
,3
]}

Begg, Bridget E. ^{[1
,2
,3
]}

Braun, Pascal ^{[1
,2
,3
]}

Brehme, Marc ^{[1
,2
,3
]}

Broly, Martin P. ^{[1
,2
,3
]}

Carvunis, Anne-Ruxandra ^{[1
,2
,3
]}

Convery-Zupan, Dan ^{[1
,2
,3
]}

Corominas, Roser ^{[17
]}

Coulombe-Huntington, Jasmin ^{[1
,2
,18
]}

Dann, Elizabeth ^{[1
,2
,3
]}

Dreze, Matija ^{[1
,2
,3
]}

Dricot, Amelie ^{[1
,2
,3
]}

Fan, Changyu ^{[1
,2
,3
]}

Franzosa, Eric ^{[1
,2
,18
]}

Gebreab, Fana ^{[1
,2
,3
]}

Gutierrez, Bryan J. ^{[1
,2
,3
]}

Hardy, Madeleine F. ^{[1
,2
,3
]}

Jin, Mike ^{[1
,2
,3
]}

Kang, Shuli ^{[17
]}

Kiros, Ruth ^{[1
,2
,3
]}

Lin, Guan Ning ^{[3
,17
]}

Luck, Katja ^{[1
,2
,3
]}

MacWilliams, Andrew ^{[1
,2
,3
]}

Menche, Joerg ^{[1
,2
,15
,16
]}

Murray, Ryan R. ^{[1
,2
,3
]}

Palagi, Alexandre ^{[1
,2
,3
]}

Poulin, Matthew M. ^{[1
,2
,3
]}

Rambout, Xavier ^{[1
,2
,3
,19
]}

Rasla, John ^{[1
,2
,3
]}

Reichert, Patrick ^{[1
,2
,3
]}

Romero, Viviana ^{[1
,2
,3
]}

Ruyssinck, Elien ^{[11
]}

Sahalie, Julie M. ^{[1
,2
,3
]}

Scholz, Annemarie ^{[1
,2
,3
]}

Shah, Akash A. ^{[1
,2
,3
]}

Sharma, Amitabh ^{[1
,2
,15
,16
]}

机构：

[1] Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[3] Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA

[4] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada

[5] Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada

[6] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada

[7] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada

[8] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[9] Boston Univ, Sch Med, Boston, MA 02118 USA

[10] Wright State Univ, Dept Biol Sci, Dayton, OH 45435 USA

[11] VIB, Dept Med Prot Res, B-9000 Ghent, Belgium

[12] Univ Salamanca, Canc Res Ctr, E-37008 Salamanca, Spain

[13] CSIC, Salamanca 37008, Spain

[14] Inst Res Biomed IRB Barcelona, Joint IRB BSC Program Computat Biol, Barcelona 08028, Spain

[15] Northeastern Univ, CCNR, Boston, MA 02115 USA

[16] Northeastern Univ, Dept Phys, Boston, MA 02115 USA

[17] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[18] McGill Univ, Dept Bioengn, Montreal, PQ H3A 0C3, Canada

[19] Univ Liege, GIGA R, Prot Signaling & Interact Lab, B-4000 Liege, Belgium

[20] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[21] ICREA, Barcelona 08010, Spain

[22] Canadian Inst Adv Res, Toronto, ON M5G 1Z8, Canada

来源：

CELL | 2014年 / 159卷 / 05期

基金：

美国国家科学基金会; 加拿大自然科学与工程研究理事会;

关键词：

MOLECULAR INTERACTION DATABASE; GENOME-WIDE ASSOCIATION; POSTTRANSLATIONAL MODIFICATIONS; COMPREHENSIVE RESOURCE; GENE; EXPRESSION; CENSUS; DRAFT; LOCI;

D O I：

10.1016/j.cell.2014.10.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand geno-type- phenotype relationships. Here, we describe a systematic map of similar to 14,000 high-quality human binary protein-protein interactions. At equal quality, this map is similar to 30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a "broader'' human interactome network than currently appreciated. The map also uncovers significant inter-connectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots'' of the genomic revolution.

引用

页码：1212 / 1226

页数：15

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