Coevolution of genomic intron number and splice sites

被引：84

作者：

Irimia, Manuel

Penny, David

Roy, Scott W. ^{[1
]}

机构：

[1] Massey Univ, Allan Wilson Ctr Mol Evolut & Ecol, Palmerston North, New Zealand

[2] Univ Barcelona, Dept Genet, E-08028 Barcelona, Spain

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 07期

关键词：

MESSENGER-RNA; EVOLUTION; CONSERVATION; GENES; TRANSCRIPTS; DATABASE; PROTEIN; GAIN;

D O I：

10.1016/j.tig.2007.04.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Spliceosomal intron numbers and boundary sequences vary dramatically in eukaryotes. We found a striking correspondence between low intron number and strong sequence conservation of 5' splice sites (5'ss) across eukaryotic genomes. The phylogenetic pattern suggests that ancestral 5'ss were relatively weakly conserved, but that some lineages independently underwent both major intron loss and 5'ss strengthening. It seems that eukaryotic ancestors had relatively large intron numbers and 'weak' 5'ss, a pattern associated with frequent alternative splicing in modern organisms.

引用

页码：321 / 325

页数：5

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