The utility of ground-glass attenuation score for anticancer treatment-related acute exacerbation of interstitial lung disease among lung cancer patients with interstitial lung disease

被引：24

作者：

Nishiyama, Naoki ^{[1
]}

Honda, Takayuki ^{[1
]}

Sema, Manabu ^{[1
]}

Kawahara, Tatsuo ^{[1
]}

Jin, Yasuto ^{[2
]}

Natsume, Ichiro ^{[3
]}

Chiaki, Tomoshige ^{[4
]}

Yamashita, Takaaki ^{[5
]}

Tsukada, Yoshikazu ^{[6
]}

Taki, Reiko ^{[7
]}

Miyashita, Yoshihiro ^{[8
]}

Saito, Kazuhito ^{[9
]}

Tateishi, Tomoya ^{[1
]}

Sakashita, Hiroyuki ^{[1
,3
,10
]}

Miyazaki, Yasunari ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Resp Med, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

[2] Hiratsuka Kyosai Hosp, Dept Resp Med, 9-11 Oiwake, Hiratsuka, Kanagawa 2548502, Japan

[3] Yokosuka Kyosai Hosp, Dept Resp Med, 1-16 Yonegahama Dori, Yokosuka, Kanagawa 2388558, Japan

[4] Hokushin Gen Hosp, Dept Resp Med, Nakano Ku, 1-5-63 Nishi, Nagano 3838505, Japan

[5] Japan Agr Cooperat, Toride Med Ctr, Dept Resp Med, 2-1-1 Hongo, Toride, Ibaraki 3020022, Japan

[6] Soka Municipal Hosp, Dept Resp Med, 2-21-1 Soka, Soka, Saitama 3408560, Japan

[7] Japanese Red Cross Musashino Hosp, Dept Resp Med, 1-26-1 Kyonancho, Musashino, Tokyo 1808610, Japan

[8] Yamanashi Prefectural Cent Hosp, Dept Resp Med, 1-1-1 Fujimi, Kofu, Yamanashi 4008506, Japan

[9] Tsuchiura Kyodo Gen Hosp, Dept Resp Med, 4-1-1 Otsuno, Tsuchiura, Ibaraki 3000028, Japan

[10] Yokosuka Kyosai Hosp, Dept Chemotherapy, 1-16 Yonegahama Dori, Yokosuka, Kanagawa 2388558, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2020年 / 25卷 / 02期

关键词：

Acute exacerbation; Chemotherapy; HRCT score; Interstitial pneumonia; Immune checkpoint inhibitor; IDIOPATHIC PULMONARY-FIBROSIS; CHEMOTHERAPY-RELATED EXACERBATION; PLUS CARBOPLATIN; RISK-FACTOR; OPEN-LABEL; PNEUMONIA; RESECTION; EXPRESSION; NIVOLUMAB; IMPACT;

D O I：

10.1007/s10147-019-01576-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Acute exacerbation (AE) of interstitial lung disease (ILD) is a fatal adverse event in the treatment of lung cancer patients with ILD. The value of pre-treatment radiological findings obtained by high-resolution computed tomography for the detection of anticancer treatment-related AE of ILD has not been established. Methods Two medical record-based retrospective studies were performed. The chemotherapy cohort included 105 lung cancer patients with ILD who received chemotherapy at Tokyo Medical and Dental University between October 2008 and December 2017. The immune checkpoint inhibitor (ICI) cohort included 48 advanced non-small cell lung cancer patients with ILD treated with ICIs at nine institutions between January 2016 and September 2018. Variables were compared between AE-positive and -negative groups. Candidate variables were analyzed by multivariate logistic regression. A P value < 0.05 was considered statistically significant. Results Anticancer treatment-related AE of ILD occurred in 12 patients (11.4%) in the chemotherapy cohort and seven patients (14.5%) in the ICI cohort. In the multivariate logistic regression analysis, ground-glass attenuation (GGA) score was the only factor significantly associated with the development of AE of ILD in both cohorts (P = 0.037 and 0.01 in the chemotherapy and ICI cohorts, respectively). Conclusion Evaluation of GGA may help predict anticancer treatment-related AE of ILD.

引用

页码：282 / 291

页数：10

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