A Differential Circuit via Retino-Colliculo-Pulvinar Pathway Enhances Feature Selectivity in Visual Cortex through Surround Suppression

被引：70

作者：

Fang, Qi ^{[1
,3
]}

Chou, Xiao-lin ^{[1
,3
]}

Peng, Bo ^{[1
,3
]}

Zhong, Wen ^{[1
]}

Zhang, Li I. ^{[1
,2
]}

Tao, Huizhong Whit ^{[1
,2
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Physiol & Neurosci, Los Angeles, CA 90089 USA

[3] Univ Southern Calif, Grad Program Neurosci, Los Angeles, CA 90089 USA

来源：

NEURON | 2020年 / 105卷 / 02期

关键词：

LATERAL GENICULATE-NUCLEUS; SUPERIOR COLLICULUS; ORIENTATION SELECTIVITY; RESPONSE PROPERTIES; RECEPTIVE-FIELDS; THALAMIC NUCLEI; TECTORECIPIENT ZONE; SPATIAL INTEGRATION; MOUSE; INHIBITION;

D O I：

10.1016/j.neuron.2019.10.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the mammalian visual system, information from the retina streams into parallel bottom-up pathways. It remains unclear how these pathways interact to contribute to contextual modulation of visual cortical processing. By optogenetic inactivation and activation of mouse lateral posterior nucleus (LP) of thalamus, a homolog of pulvinar, or its projection to primary visual cortex (V1), we found that LP contributes to surround suppression of layer (L) 2/3 responses in V1 by driving Ll inhibitory neurons. This results in subtractive suppression of visual responses and an overall enhancement of orientation, direction, spatial, and size selectivity. Neurons in V1-projecting LP regions receive bottom-up input from the superior colliculus (SC) and respond preferably to non-patterned visual noise. The noise-dependent LP activity allows V1 to "cancel" noise effects and maintain its orientation selectivity under varying noise background. Thus, the retina-SC-LP-V1 pathway forms a differential circuit with the canonical retino-geniculate pathway to achieve context-dependent sharpening of visual representations.

引用

页码：355 / +

页数：21