[18F]FDG uptake of axillary lymph nodes after COVID-19 vaccination in oncological PET/CT: frequency, intensity, and potential clinical impact

被引：40
作者：
Skawran, Stephan [1 ,2 ]
Gennari, Antonio G. [1 ,2 ]
Dittli, Manuel [1 ,2 ]
Treyer, Valerie [1 ,2 ]
Muehlematter, Urs J. [1 ,2 ]
Maurer, Alexander [1 ,2 ]
Burger, Irene A. [1 ,2 ,3 ]
Mader, Cacilia [1 ,2 ]
Messerli, Olivia [2 ,4 ]
Grunig, Hannes [1 ,2 ]
Gebhard, Catherine [1 ,2 ]
Huellner, Martin W. [1 ,2 ]
Curioni-Fontecedro, Alessandra [2 ,5 ]
Berger, Christoph [2 ,6 ,7 ]
Messerli, Michael [1 ,2 ]
机构：
[1] Univ Hosp Zurich, Dept Nucl Med, Ramistr 100, CH-8091 Zurich, Switzerland
[2] Univ Zurich, Zurich, Switzerland
[3] Kantonsspital Baden, Dept Nucl Med, Baden, Switzerland
[4] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland
[5] Univ Hosp Zurich, Dept Med Oncol & Hematol, Zurich, Switzerland
[6] Univ Childrens Hosp Zurich, Div Infect Dis, Zurich, Switzerland
[7] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland
来源：
EUROPEAN RADIOLOGY | 2022年 / 32卷 / 01期
关键词：
COVID-19; vaccines; Lymph nodes; Fluorodeoxyglucose F18; Positron-emission tomography;
D O I：
10.1007/s00330-021-08122-2
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objectives To assess the frequency, intensity, and clinical impact of [F-18]FDG-avidity of axillary lymph nodes after vaccination with COVID-19 vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) in patients referred for oncological FDG PET/CT. Methods One hundred forty patients referred for FDG PET/CT during February and March 2021 after first or second vaccination with Pfizer-BioNTech or Moderna were retrospectively included. FDG-avidity of ipsilateral axillary lymph nodes was measured and compared. Assuming no knowledge of prior vaccination, metastatic risk was analyzed by two readers and the clinical impact was evaluated. Results FDG PET/CT showed FDG-avid lymph nodes ipsilateral to the vaccine injection in 75/140 (54%) patients with a mean SUVmax of 5.1 (range 2.0 - 17.3). FDG-avid lymph nodes were more frequent in patients vaccinated with Moderna than Pfizer-BioNTech (36/50 [72%] vs. 39/90 [43%] cases, p < 0.001). Metastatic risk of unilateral FDG-avid axillary lymph nodes was rated unlikely in 52/140 (37%), potential in 15/140 (11%), and likely in 8/140 (6%) cases. Clinical management was affected in 17/140 (12%) cases. Conclusions FDG-avid axillary lymph nodes are common after COVID-19 vaccination. The avidity of lymph nodes is more frequent in Moderna compared to that in Pfizer-BioNTech vaccines. To avoid relatively frequent clinical dilemmas, we recommend carefully taking the history for prior vaccination in patients undergoing FDG PET/CT and administering the vaccine contralateral to primary cancer.
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收藏
页码：508 / 516
页数：9
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