Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

被引：347
作者：
Bernadotte, Alexandra [1 ,2 ]
Mikhelson, Victor M. [3 ]
Spivak, Irina M. [3 ,4 ,5 ]
机构：
[1] Karolinska Inst, Dept Med Biochem & Biophys, S-14157 Huddinge, Sweden
[2] Russian Acad Sci, St Petersburg Inst Bioregulat & Gerontol, St Petersburg 197110, Russia
[3] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia
[4] St Petersburg State Univ, St Petersburg 199034, Russia
[5] St Petersburgs Polytech State Univ, St Petersburg 195251, Russia
来源：
AGING-US | 2016年 / 8卷 / 01期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
cellular senescence; telomere; replicative senescence; aging; biomarkers; telomere theory; DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; HETEROCHROMATIN FOCI; BETA-GALACTOSIDASE; HUMAN FIBROBLASTS; HISTONE H2AX; HUMAN-CELLS; DYSKERATOSIS-CONGENITA; PREMATURE SENESCENCE; GENOMIC INSTABILITY;
D O I：
10.18632/aging.100871
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.
引用
收藏
页码：3 / 11
页数：9
相关论文
共 102 条
[1]   TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].
ALLSOPP, RC ;
VAZIRI, H ;
PATTERSON, C ;
GOLDSTEIN, S ;
YOUNGLAI, EV ;
FUTCHER, AB ;
GREIDER, CW ;
HARLEY, CB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118
[2]   The telomere syndromes [J].
Armanios, Mary ;
Blackburn, Elizabeth H. .
NATURE REVIEWS GENETICS, 2012, 13 (10) :693-704
[3]   Telomeres, sex, reactive oxygen species, and human cardiovascular aging [J].
Aviv, A .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2002, 80 (11) :689-695
[4]   Genes and pathways downstream of telomerase in melanoma metastasis [J].
Bagheri, Sepideh ;
Nosrati, Mehdi ;
Li, Shang ;
Fong, Sylvia ;
Torabian, Sima ;
Rangel, Javier ;
Moore, Dan H. ;
Federman, Scot ;
LaPosa, Rebecca R. ;
Baehner, Frederick L. ;
Sagebiel, Richard W. ;
Cleaver, James E. ;
Haqq, Christopher ;
Debs, Robert J. ;
Blackburn, Elizabeth H. ;
Kashani-Sabet, Mohammed .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11306-11311
[5]   Replication protein A and γ-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks [J].
Balajee, AS ;
Geard, CR .
EXPERIMENTAL CELL RESEARCH, 2004, 300 (02) :320-334
[6]   The wide-ranging clinical implications of the short telomere syndromes [J].
Barbaro, P. M. ;
Ziegler, D. S. ;
Reddel, R. R. .
INTERNAL MEDICINE JOURNAL, 2016, 46 (04) :393-403
[7]   No association between telomere length and survival among the elderly and oldest old [J].
Bischoff, C ;
Petersen, HC ;
Graakjaer, J ;
Andersen-Ranberg, K ;
Vaupel, JW ;
Bohr, VA ;
Kolvraa, S ;
Christensen, K .
EPIDEMIOLOGY, 2006, 17 (02) :190-194
[8]   Dysfunctional telomeres promote genomic instability and metastasis in the absence of telomerase activity in oncogene induced mammary cancer [J].
Bojovic, Bojana ;
Crowe, David L. .
MOLECULAR CARCINOGENESIS, 2013, 52 (02) :103-117
[9]   Telomere shortening and haemodialysis [J].
Boxall, MC ;
Goodship, THJ ;
Brown, AL ;
Ward, MC ;
von Zglinicki, T .
BLOOD PURIFICATION, 2006, 24 (02) :185-189
[10]   Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer [J].
Broberg, K ;
Björk, J ;
Paulsson, K ;
Höglund, M ;
Albin, M .
CARCINOGENESIS, 2005, 26 (07) :1263-1271
12345678910