Double-Edged Genetic Swords and Immunity: Lesson from CCR5 and Beyond

被引:7
作者
Ahuja, Sunil K. [1 ,2 ]
He, Weijing [1 ,2 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Vet Adm Res Ctr AIDS & HIV Infect 1, S Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA
关键词
WEST-NILE-VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; CHEMOKINE RECEPTOR CCR5; MACROPHAGE-TROPIC HIV-1; IN-VITRO; MIP-1; ALPHA; VIRAL ENTRY; INFECTION; DENSITY; SUSCEPTIBILITY;
D O I
10.1086/649427
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:171 / 174
页数:4
相关论文
共 43 条
  • [1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    Alkhatib, G
    Combadiere, C
    Broder, CC
    Feng, Y
    Kennedy, PE
    Murphy, PM
    Berger, EA
    [J]. SCIENCE, 1996, 272 (5270) : 1955 - 1958
  • [2] Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    Berger, EA
    Murphy, PM
    Farber, JM
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 657 - 700
  • [3] Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies
    Blanpain, C
    Vanderwinden, JM
    Cihak, J
    Wittamer, V
    Le Poul, E
    Issafras, H
    Stangassinger, M
    Vassart, G
    Marullo, S
    Schlöndorff, D
    Parmentier, M
    Mack, M
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (02) : 723 - 737
  • [4] West Nile Virus-Specific CD4 T Cells Exhibit Direct Antiviral Cytokine Secretion and Cytotoxicity and Are Sufficient for Antiviral Protection
    Brien, James D.
    Uhrlaub, Jennifer L.
    Nikolich-Zugich, Janko
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (12) : 8568 - 8575
  • [5] CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation
    Camargo, Jose F.
    Quinones, Marlon P.
    Mummidi, Srinivas
    Srinivas, Sowmya
    Gaitan, Alvaro A.
    Begum, Kazi
    Jimenez, Fabio
    VanCompernolle, Scott
    Unutmaz, Derya
    Ahuja, Seema S.
    Ahuja, Sunil K.
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 182 (01) : 171 - 182
  • [6] Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1 alpha, MIP-1 beta, and RANTES
    Combadiere, C
    Ahuja, SK
    Tiffany, HL
    Murphy, PM
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 60 (01) : 147 - 152
  • [7] A genetic basis for human susceptibility to West Nile virus
    Diamond, Michael S.
    Klein, Robyn S.
    [J]. TRENDS IN MICROBIOLOGY, 2006, 14 (07) : 287 - 289
  • [8] CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms
    Dolan, Matthew J.
    Kulkarni, Hemant
    Camargo, Jose F.
    He, Weijing
    Smith, Alison
    Anaya, Juan-Manuel
    Miura, Toshiyuki
    Hecht, Frederick M.
    Mamtani, Manju
    Pereyra, Florencia
    Marconi, Vincent
    Mangano, Andrea
    Sen, Luisa
    Bologna, Rosa
    Clark, Robert A.
    Anderson, Stephanie A.
    Delmar, Judith
    O'Connell, Robert J.
    Lloyd, Andrew
    Martin, Jeffrey
    Ahuja, Seema S.
    Agan, Brian K.
    Walker, Bruce D.
    Deeks, Steven G.
    Ahuja, Sunil K.
    [J]. NATURE IMMUNOLOGY, 2007, 8 (12) : 1324 - 1336
  • [9] IN-VITRO T-CELL FUNCTION, DELAYED-TYPE HYPERSENSITIVITY SKIN TESTING, AND CD4(+) T-CELL SUBSET PHENOTYPING INDEPENDENTLY PREDICT SURVIVAL-TIME IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS
    DOLAN, MJ
    CLERICI, M
    BLATT, SP
    HENDRIX, CW
    MELCHER, GP
    BOSWELL, RN
    FREEMAN, TM
    WARD, W
    HENSLEY, R
    SHEARER, GM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (01) : 79 - 87
  • [10] Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
    Dorr, P
    Westby, M
    Dobbs, S
    Griffin, P
    Irvine, B
    Macartney, M
    Mori, J
    Rickett, G
    Smith-Burchnell, C
    Napier, C
    Webster, R
    Armour, D
    Price, D
    Stammen, B
    Wood, A
    Perros, M
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (11) : 4721 - 4732