Formal Total Synthesis of (±)-Cephalotaxine and Congeners via Aryne Insertion Reaction

被引：58

作者：

Gouthami, Pashikanti ^{[1
]}

Chegondi, Rambabu ^{[1
]}

Chandrasekhar, Srivari ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 09期

关键词：

CEPHALOTAXUS ALKALOIDS; STEREOSELECTIVE-SYNTHESIS; MOLECULAR-STRUCTURE; EFFICIENT SYNTHESIS; ANALOGS; ALKYLATION; CRYSTAL; ACCESS;

D O I：

10.1021/acs.orglett.6b00659

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formal total synthesis of pentacyclic core alkaloid, (+/-)-cephalotaxine is achieved in nine steps from known 2-allylpyrrolidine-2-carboxaldehyde using aryne insertion reaction as a key step in 10% overall yield. The developed novel strategy enabled easy access to cephalotaxine congeners.

引用

页码：2044 / 2046

页数：3

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