In recent years, global concerns about greenhouse gas emissions have stimulated considerable interest in CO2 storage as a potential "bridging technology", which could reduce significantly CO2 emissions, while allowing fossil fuels to be used until alternative energy sources are more widely deployed. Flow modeling is a relevant step in the characterization of a CO2 storage site, to provide quantitative predictions of reservoir behavior and assessing the uncertainty [1]. The scope of this work is to analyze the impact of CO2 injection in Pliocene offshore water-bearing sands potentially suitable for CO2 storage, through the implementation of an integrated reservoir study. The approach undertaken was first to build several geological models (local and regional), stochastically populate them with petrophysical properties and, through the gathering and generation of representative dynamic data, develop a dynamic model to simulate a set of possible CO2 injection scenarios. Furthermore a base case scenario was identified to perform a comparison between two different simulators: COORES (TM), a code designed by IFPEN, and ECLIPSE300 - CO2STORE (TM), the Schlumberger compositional tool designed specifically for CO2 storage in saline aquifers. (C) 2013 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).