Enantioselective Hydrogenation of Olefins using Commercially Available Pd/C. Chiral Heterogeneous Catalyst Applicable for High-Throughput Screening

被引：11

作者：

Kim, Tae Yeon ^{[1
]}

Uchida, Takayuki ^{[1
]}

Ogawa, Hiroyuki ^{[1
]}

Nitta, Yuriko ^{[1
]}

Okuyama, Tadashi ^{[1
]}

Sugimura, Takashi ^{[1
]}

Hirayama, Sayaka ^{[2
]}

Honma, Tetsuo ^{[2
]}

Sugiura, Masahiro ^{[2
]}

Kubota, Takeshi ^{[3
]}

Okamoto, Yasuaki ^{[3
]}

机构：

[1] Hyogo Med Univ, Grad Sch Mat Sci, Kamigori, Hyogo 6781297, Japan

[2] Japan Synchrotron Radiat Res Inst, Ind Applicat Div, Sayo, Hyogo 6795198, Japan

[3] Shimane Univ, Dept Mat Sci, Matsue, Shimane 6908504, Japan

来源：

TOPICS IN CATALYSIS | 2010年 / 53卷 / 1-2期

关键词：

Enantioselective hydrogenation; HT screening; Commercial Pd/C; Catalyst pretreatment; Parallel reactor; CINCHONIDINE-MODIFIED PD/TIO2; (E)-ALPHA-PHENYLCINNAMIC ACID; PALLADIUM; DEPENDENCE;

D O I：

10.1007/s11244-009-9426-7

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cinchonidine-modified Pd/C applicable for the high-throughput-guided study was developed. Commercial Pd/C catalysts were employed for the enantioselective hydrogenation of phenylcinnamic acid after the pretreatment, and some of the catalysts were found to result in the sufficient enantioselectivity. The Pd/C catalysts suitable for the cinchonidine modification were characterized by TEM and XAFS to have highly dispersed metal, 2.2 nm of the mean particles size for the best catalyst. The pre-modified Pd/C could be stored in a suspension accompanying with gradual decease in the product ee. The pre-modified catalyst was applicable for the high-throughput screening by using a parallel reactor in the 1/5-scale reactions.

引用

页码：116 / 122

页数：7

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