Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response

被引：11

作者：

Simpson, Morgan ^{[1
]}

Frisbee, Alyse ^{[2
]}

Kumar, Pankaj ^{[3
]}

Schwan, Carsten ^{[4
]}

Aktories, Klaus ^{[4
]}

Petri, William A., Jr. ^{[1
,2
,5
]}

机构：

[1] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA

[2] Univ Virginia, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA USA

[3] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA

[4] Univ Freiburg, Fac Med, Inst Expt & Clin Pharmacol & Toxicol, Freiburg, Germany

[5] Univ Virginia, Dept Med, Charlottesville, VA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2022年 / 225卷 / 07期

关键词：

Clostridioides dfficile; CDT; binary toxin; immune response; innate immunity; TLR2; TLR6; NF-kappa B;

D O I：

10.1093/infdis/jiaa620

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clostridioides difficile infection (CDI) represents a significant burden on the health care system, one that is exacerbated by the emergence of binary toxin (CDT)-producing hypervirulent C. difficile strains. Previous work from our laboratory has shown that Toll-like receptor 2 (TLR2) recognizes CDT to induce inflammation. Here we explore the interactions of CDT with TLR2 and the impact on host immunity during CDI. We found that the TLR2/6 heterodimer, not TLR2/1, is responsible for CDT recognition, and that gene pathways including nuclear factor-KB and MAPK downstream of TLR2/6 are upregulated in mice with intact TLR2/6 signaling during CDI.

引用

页码：1296 / 1300

页数：5

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