Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series

被引:0
作者
Thientunyakit, Tanyaluck [1 ,2 ]
Thongpraparn, Thonnapong [1 ]
Siriprapa, Tossaporn [1 ]
Gelovani, Juri G. [3 ,4 ]
机构
[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Radiol,Div Nucl Med, Bangkok 10700, Thailand
[2] Mahidol Univ, Siriraj Hosp, Fac Med, NANOTEC,Ctr Excellence Nanotechnol Canc Diagnosis, Bangkok, Thailand
[3] Wayne State Univ, Sch Med, Coll Engn, Dept Neurosurg,Oncol,OBGYN,Biomed Engn, Detroit, MI USA
[4] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA
关键词
18F]-2'-fluoro-2'-deoxy-D-glucose; 18F]-fluorocholine; choriocarcinoma; gestational trophoblastic neoplasia; positron emission tomography; computed tomography; CHOLINE;
D O I
10.4103/wjnm.WJNM_91_18
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [18F]-2'-fluoro-2'-deoxy-D-glucose ([18F]-FDG) and [18F]-fluorocholine ([18F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [18F]-FDG and [18F]-FCH was performed in three patients with GTN in 2 consecutive days. Each detectable lesion was characterized by visual and quantitative analyses. As compared to CT alone, PET/CT with [18F]-FDG and [18F]-FCH PET/CT revealed more hypermetabolic metastatic lesions in the body, but not in the brain. The standard uptake value of [18F]-FDG was generally higher than [18F]-FCH in all detectable tumor lesions. In conclusion, both [18F]-FDG and [18F]-FCH PET/CT can be used for diagnosis and staging for GTN, based on their sensitivity for small extracerebral metastatic lesions. Additional studies are warranted to determine whether the PET/CT imaging with [18F]-FDG and [18F]-FCH can serve as a biomarker of GTN aggressiveness, for prediction of treatment response.
引用
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页码:72 / 77
页数:6
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