Targeted salinomycin delivery with EGFR and CD133 aptamers based dual-ligand lipid-polymer nanoparticles to both osteosarcoma cells and cancer stem cells

被引：61

作者：

Chen, Fangyi ^{[1
]}

Zeng, Yibin ^{[2
]}

Qi, Xiaoxia ^{[3
]}

Chen, Yanchao ^{[1
]}

Ge, Zhe ^{[1
]}

Jiang, Zengxin ^{[1
]}

Zhang, Xinchao ^{[1
]}

Dong, Yinmei ^{[5
]}

Chen, Huaiwen ^{[4
,5
]}

Yu, Zuochong ^{[1
]}

机构：

[1] Fudan Univ, Dept Orthoped, Jinshan Hosp, 1508 Longhang Rd, Shanghai, Peoples R China

[2] Cent Hosp Minhang Dist, Dept Dermatol, Shanghai, Peoples R China

[3] Fudan Univ, Wound Care Ctr, Jinshan Hosp, Shanghai, Peoples R China

[4] Sunlipo Biotech Res Ctr Nanomed, 3688 Tingwei Rd, Shanghai 201507, Peoples R China

[5] Shanghai Changhai Hosp, Ctr Clin & Translat Med, 3688 Tingwei Rd, Shanghai 201507, Peoples R China

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Osteosarcoma; Cancer stem cells; CD133; EGFR; Dual targeting; DRUG-DELIVERY; HYBRID NANOPARTICLES; THERAPY; EQUILIBRIUM; EXPRESSION; CODELIVERY; DONATION; STATE;

D O I：

10.1016/j.nano.2018.05.015

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We previously developed salinomycin (sali)-entrapped nanoparticles labeled with CD133 aptamers which could efficiently eliminate CD133(+) osteosarcoma cancer stem cells (CSCs). However, sufficient evidences suggest that the simultaneous targeting both CSCs and cancer cells is pivotal in achieving preferable cancer therapeutic efficacy, due to the spontaneous conversion between cancer cells and CSCs. We hereby constructed sali-entrapped lipid-polymer nanoparticles labeled with CD133 and EGFR aptamers (CESP) to target both osteosarcoma cells and CSCs. The cytotoxicity of CESP in osteosarcoma cells and CSCs was superior to that of single targeting or nontargeted sali-loaded nanoparticles. Administration of CESP in vivo showed the best efficacy in inhibiting tumor growth than other controls in osteosarcoma-bearing mice. Thus, CESP was demonstrated to be capable of efficiently targeting both osteosarcoma CSCs and cancer cells, and it represents an effective potential approach to treat osteosarcoma. (c) 2018 Elsevier Inc. All rights reserved.

引用

页码：2115 / 2127

页数：13

共 32 条

[31] Novel CD44 receptor targeting multifunctional "nano-eggs" based on double pH-sensitive nanoparticles for co-delivery of curcumin and paclitaxel to cancer cells and cancer stem cells
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Wang, Guohua
Song, Weiguo
Zhang, Qiang
JOURNAL OF NANOPARTICLE RESEARCH, 2015, 17 (10)
[32] Novel CD44 receptor targeting multifunctional “nano-eggs” based on double pH-sensitive nanoparticles for co-delivery of curcumin and paclitaxel to cancer cells and cancer stem cells
Daquan Chen
Guohua Wang
Weiguo Song
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Journal of Nanoparticle Research, 2015, 17

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