Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery

被引：718
作者：
Bromberg, LE [1 ]
Ron, ES [1 ]
机构：
[1] Sensei Pharmaceut, Lexington, MA 02173 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 31卷 / 03期
关键词：
pluronic-g-poly(acrylic acid) conjugates; pluronic surfactants; poly(ethylene oxide) and poly(propylene oxide) triblock copolymers; protein and peptide delivery; temperature-sensitive polymers;
D O I：
10.1016/S0169-409X(97)00121-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The explosive development of protein and peptide drugs has ushered in a great need for effective delivery systems for such drugs. Two decades of studies of protein delivery from polymeric systems has revealed the great potential of gels that respond to environmental stimuli, such as temperature. Protein and peptide release can be engineered to occur in a pulsatile mode. The mechanism of this release is greatly affected by polymer design. 'Intelligent' amphiphilic copolymers emerge as a novel trend in the application of thermodynamically stable self-assembling lyophilic colloids to protein and peptide delivery. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：197 / 221
页数：25
相关论文
共 247 条
[1]   EFFECT OF TEMPERATURE ON THE RELEASE RATE OF BIOMOLECULES FROM THERMALLY REVERSIBLE HYDROGELS [J].
AFRASSIABI, A ;
HOFFMAN, AS ;
CADWELL, LA .
JOURNAL OF MEMBRANE SCIENCE, 1987, 33 (02) :191-200
[2]   Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer [J].
Alakhov, VY ;
Moskaleva, EY ;
Batrakova, EV ;
Kabanov, AV .
BIOCONJUGATE CHEMISTRY, 1996, 7 (02) :209-216
[3]  
ALAKHOV VY, 1994, Patent No. 08564
[4]   Amphiphilic copolymers and their applications [J].
Alexandridis, P .
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 1996, 1 (04) :490-501
[5]   MICELLIZATION OF POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) TRIBLOCK COPOLYMERS IN AQUEOUS-SOLUTIONS - THERMODYNAMICS OF COPOLYMER ASSOCIATION [J].
ALEXANDRIDIS, P ;
HOLZWARTH, JF ;
HATTON, TA .
MACROMOLECULES, 1994, 27 (09) :2414-2425
[6]   POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) BLOCK-COPOLYMER SURFACTANTS IN AQUEOUS-SOLUTIONS AND AT INTERFACES - THERMODYNAMICS, STRUCTURE, DYNAMICS, AND MODELING [J].
ALEXANDRIDIS, P ;
HATTON, TA .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1995, 96 (1-2) :1-46
[7]   Lyotropic liquid crystallinity in amphiphilic block copolymers: Temperature effects on phase behavior and structure for poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) copolymers of different composition [J].
Alexandridis, P ;
Zhou, DL ;
Khan, A .
LANGMUIR, 1996, 12 (11) :2690-2700
[8]   TEMPERATURE EFFECTS ON STRUCTURAL-PROPERTIES OF PLURONIC P104 AND F108 PEO-PPO-PEO BLOCK-COPOLYMER SOLUTIONS [J].
ALEXANDRIDIS, P ;
NIVAGGIOLI, T ;
HATTON, TA .
LANGMUIR, 1995, 11 (05) :1468-1476
[9]  
Almdal K., 1993, POLYM GELS NETW, V1, P5, DOI DOI 10.1016/0966-7822(93)90020-I
[10]   AGGREGATION OF POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) TRIBLOCK COPOLYMERS IN THE PRESENCE OF SODIUM DODECYL-SULFATE IN AQUEOUS-SOLUTION [J].
ALMGREN, M ;
VANSTAM, J ;
LINDBLAD, C ;
LI, PY ;
STILBS, P ;
BAHADUR, P .
JOURNAL OF PHYSICAL CHEMISTRY, 1991, 95 (14) :5677-5684
12345678910