Pimecrolimus - A review of its use in atopic dermatitis

被引:15
作者
Wellington, K [1 ]
Noble, S [1 ]
机构
[1] Adis Int Ltd, Yardley, PA 19067 USA
关键词
pimecrolimus; atopic dermatitis; pharmacodynamics; pharmacokinetics; therapeutic use; tolerability;
D O I
10.2165/00128071-200405060-00013
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Sources: Medical literature published in any language since 1980 on pimecrolimus, identified using Medline and EMBASE, supplemented by AdisBase (a proprietary database of Adis International). Additional references were identified from the reference lists of published articles. Bibliographical information, including contributory unpublished data, was also requested from the company developing the drug. Search strategy: Medline and EMBASE search terms were 'pimecrolimus'. AdisBase search terms were 'pimecrolimus' or 'ASM 981' or 'SDZ ASM 981'. Searches were last updated 23 November 2004. Selection: Studies in patients with atopic dermatitis who received pimecrolimus. Inclusion of studies was based mainly on the methods section of the trials. When available, large, well controlled trials with appropriate statistical methodology were preferred. Relevant pharmacodynamic and pharmacokinetic data are also included.
引用
收藏
页码:479 / 495
页数:17
相关论文
共 83 条
[1]   Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patients [J].
Allen, BR ;
Lakhanpaul, M ;
Morris, A ;
Lateo, S ;
Davies, T ;
Scott, G ;
Cardno, M ;
Ebelin, ME ;
Burtin, P ;
Stephenson, TJ .
ARCHIVES OF DISEASE IN CHILDHOOD, 2003, 88 (11) :969-973
[2]  
ANTAYA R, 2004, 30 ANN M SOC PED DER
[3]   Childhood atopic eczema [J].
Barnetson, RS ;
Rogers, M .
BRITISH MEDICAL JOURNAL, 2002, 324 (7350) :1376-1379
[4]   Relationship between quality of life and disease severity in atopic dermatitis/eczema syndrome during childhood [J].
Ben-Gashir, Mohamed A. .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 3 (05) :369-373
[5]  
Billich A, 2004, J INVEST DERMATOL, V122, pA40
[6]   Percutaneous absorption of drugs used in atopic eczema:: pimecrolimus permeates less through skin than corticosteroids and tacrolimus [J].
Billich, A ;
Aschauer, H ;
Aszódi, A ;
Stuetz, A .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2004, 269 (01) :29-35
[7]  
BINGHAM A, 2002, 20 WORLD C DERM JUL
[8]  
Boguniewicz Mark, 2003, Journal of Allergy and Clinical Immunology, V112, pS140, DOI 10.1016/j.jaci.2003.09.031
[9]   Topical corticosteroid phobia in patients with atopic eczema [J].
Charman, CR ;
Morris, AD ;
Williams, HC .
BRITISH JOURNAL OF DERMATOLOGY, 2000, 142 (05) :931-936
[10]   Tacrolimus ointment: A review of its therapeutic potential as a topical therapy in atopic dermatitis [J].
Cheer S.M. ;
Plosker G.L. .
American Journal of Clinical Dermatology, 2001, 2 (6) :389-406