Differential patterns of striatal activation in young children with and without ADHD

被引:474
作者
Durston, S
Tottenham, NT
Thomas, KM
Davidson, MC
Eigsti, IM
Yang, YH
Ulug, AM
Casey, BJ
机构
[1] Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, New York, NY 10021 USA
[2] Univ Utrecht, Med Ctr, Dept Child & Adolescent Psychiat, Utrecht, Netherlands
[3] Columbia Univ, Sackler Inst Dev Psychobiol, New York, NY USA
[4] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY USA
关键词
ADHD; development; striatum; response inhibition; event-related fMRI; parametric;
D O I
10.1016/S0006-3223(02)01904-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Cognitive control, defined as the ability to suppress inappropriate thoughts and actions, is compromised in attention-deficit/hyperactivity disorder (ADHD). This study examines the neural basis of this deficit. Methods: We used a paradigm that incorporates a parametric manipulation within a go/nogo task, so that the number of go trials preceding a nogo trial is varied to tax the neural systems underlying cognitive control with increasing levels of interference. Results: Using this paradigm in combination with event-related functional magnetic resonance imaging (fMRI), we show that children without ADHD have increased susceptibility to interference with increasing numbers of go trials preceding a nogo trial, but children with ADHD have difficulty even with a single go trial preceding a nogo trial. In addition, children with ADHD do not activate frontostriatal regions in the same manner as normally developing children, but rather rely on a more diffuse network of regions, including more posterior and dorsolateral prefrontal regions. Conclusions: Normal immature cognition may be characterized as being susceptible to interference and supported by the maturation of frontostriatal circuitry. ADHD children show a slightly different cognitive profile at 6 to 10 years of age that is paralleled by a relative lack of or delay in the maturation of ventral frontostriatal circuitry. (C) 2003 Society of Biological Psychiatry.
引用
收藏
页码:871 / 878
页数:8
相关论文
共 47 条
[1]  
Achenback T.M., 1983, Manual for the child behavior checklist and revised child behavior profile
[2]  
*AM PSYCH ASS, 1994, DIAGN STAT MAN PSYCH
[3]   Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD [J].
Barkley, RA .
PSYCHOLOGICAL BULLETIN, 1997, 121 (01) :65-94
[4]  
Buitelaar J, 2002, HYPERACTIVITY ATTENT
[5]   Dissociable contributions of prefrontal and parietal cortices to response selection [J].
Bunge, SA ;
Hazeltine, E ;
Scanlon, MD ;
Rosen, AC ;
Gabrieli, JDE .
NEUROIMAGE, 2002, 17 (03) :1562-1571
[6]   The feasibility of a common stereotactic space for children and adults in fMRI studies of development [J].
Burgund, ED ;
Kang, HC ;
Kelly, JE ;
Buckner, RL ;
Snyder, AZ ;
Petersen, SE ;
Schlaggar, BL .
NEUROIMAGE, 2002, 17 (01) :184-200
[7]   Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop [J].
Bush, G ;
Frazier, JA ;
Rauch, SL ;
Seidman, LJ ;
Whalen, PJ ;
Jenike, MA ;
Rosen, BR ;
Biederman, J .
BIOLOGICAL PSYCHIATRY, 1999, 45 (12) :1542-1552
[8]   Age related changes in inhibitory control as measured by stop signal task performance [J].
Carver, AC ;
Livesey, DJ ;
Charles, M .
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2001, 107 (1-2) :43-61
[9]   Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging [J].
Casey, BJ ;
Thomas, KM ;
Welsh, TF ;
Badgaiyan, RD ;
Eccard, CH ;
Jennings, JR ;
Crone, EA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8728-8733
[10]   A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task [J].
Casey, BJ ;
Trainor, RJ ;
Orendi, JL ;
Schubert, AB ;
Nystrom, LE ;
Giedd, JN ;
Castellanos, FX ;
Haxby, JV ;
Noll, DC ;
Cohen, JD ;
Forman, SD ;
Dahl, RE ;
Rapoport, JL .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1997, 9 (06) :835-847