Self-report instruments for assessing adherence to warfarin therapy: a systematic review

被引：7
作者：
Vianna, Mayara Sousa [1 ]
da Silva Praxedes, Marcus Fernando [2 ]
de Araujo, Vania Eloisa [3 ]
Ferreira, Carolina Barbosa [1 ]
de Sousa, Waleska Jaclyn Freitas Nunes [4 ]
Viana, Catiane Costa [1 ]
Martins, Maria Auxiliadora Parreiras [1 ,4 ]
机构：
[1] Univ Fed Minas Gerais, Fac Farm, Av Pres Antonio Carlos,6627 Pampulha, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Reconcavo Bahia, Ctr Ciencias Saude, Av Cajueiro, Santo Antonio De Jesus, BA, Brazil
[3] Pontificia Univ Catolica Minas Gerais, Fac Odontol, Av Dom Jose Gaspar,500 Coracao Eucarist, BR-30535901 Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Fac Med, Av Prof Alfredo Balena,190,Bairro Santa Efigenia, BR-30130100 Belo Horizonte, MG, Brazil
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2021年 / 77卷 / 12期
关键词：
Anticoagulants; Medication Adherence; Validation studies; Warfarin; ATRIAL-FIBRILLATION; ANTICOAGULATION CONTROL; ORAL ANTICOAGULATION; PREDICTIVE-VALIDITY; MEDICATION; KNOWLEDGE; VALIDATION; STROKE; IMPACT;
D O I：
10.1007/s00228-021-03168-z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background The assessment of adherence to warfarin therapy is useful in clinical practice due to its wide variability in dose-response and risks of complications. The aim of this study was to investigate validated instruments used to assess adherence to warfarin therapy. Methods Information was collected from the MEDLINE (PubMed), LILACS, EMBASE, and Cochrane Library databases. Search strategies were applied for each database, with no time limit or language restriction. Inclusion criteria consisted of study participants of >= 18 years of age, from both sexes, on chronic anticoagulation with warfarin for any indication and the use of validated instruments to assess adherence to warfarin therapy. Exclusion criteria consisted of duplicate articles, narrative or systematic reviews, and meta-analyses, as well as case reports/series and experimental studies involving animals. Two independent reviewers performed the following steps: evaluation of titles/abstracts, selection of studies after full reading, data extraction, and evaluation of potential bias. Discrepancies were resolved by a third reviewer. Results Overall, 19 articles were selected for this systematic review, including 17 cross-sectional studies, one cohort study, and one quasi-experimental study, published from 2009 to 2019. The validated instruments identified in this review were Morisky Medication Adherence Scale (MMAS), the eight-item Morisky Medication Adherence Scale (MMAS-8), Measurement of Treatment Adherence (MTA), and Brief Medication Questionnaire (BMQ). Only MMAS-8 was tested for reliability, using the internal consistency assessment, with Cronbach's alpha range 0.56-0.71. Conclusions This review highlighted a gap in knowledge regarding the scarcity of validated instruments to assess adherence to warfarin therapy. Limitations were found in instruments that comprised the assessment of the isolated use of medication and the lack of analysis of other relevant therapeutic aspects. Future studies are needed to develop and validate more comprehensive instruments in an attempt to assess adherence to warfarin therapy. PROSPERO Registration number CRD42019128324
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收藏
页码：1765 / 1781
页数：17
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