Caroguaianolide A-E, five new cytotoxic sesquiterpene lactones from Carpesium abrotanoides L.

被引：18

作者：

Wang, Lei ^{[1
]}

Qin, Wen ^{[1
]}

Tian, Li ^{[1
]}

Zhang, Xue-Xue ^{[1
]}

Lin, Fang ^{[1
]}

Cheng, Fan ^{[1
]}

Chen, Jian-Feng ^{[1
]}

Liu, Cheng-Xiong ^{[1
]}

Guo, Zhi-Yong ^{[1
]}

Proksch, Peter ^{[2
]}

Zou, Kun ^{[1
]}

机构：

[1] China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R China

[2] Heinrich Heine Univ Duesseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

FITOTERAPIA | 2018年 / 127卷

关键词：

Carpesium abrotanoides L; Sesquiterpene lactones; Structural elucidation; Cytotoxic activities; GUAIANOLIDE SESQUITERPENES; EUPATORIUM-CHINENSE; PULICARIA-CRISPA; CONSTITUENTS;

D O I：

10.1016/j.fitote.2018.03.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new guaiane-type sesquiterpene lactones, caroguaianolide A-E (1-5), along with nine known sesquiterpene lactones (6-14) were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic date, HRESIMS analysis, and comparison of experimental and calculated ECD data. All isolated compounds (1-14) were tested in vitro for their cytotoxic activities against the MDA-MB-231, HGC-27 cancer cell lines, of which compounds 1-3, 6, 7, 11 and 12 showed significant cytotoxic activities with IC50 values ranging from 2.67 to 12.34 mu M.

引用

页码：349 / 355

页数：7

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