Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development

被引:10
|
作者
Bagadia, Prachi [1 ]
Huang, Xiao [1 ]
Liu, Tian-Tian [1 ]
Murphy, Kenneth M. [1 ,2 ]
机构
[1] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA
[2] Washington Univ, Howard Hughes Med Inst, Sch Med, St Louis, MO 63108 USA
关键词
transcription factors; hematopoiesis; dendritic cells; innate lymphoid cells; T cells; NATURAL-KILLER-CELL; SMAD-INTERACTING PROTEIN-1; INTERFERON-PRODUCING CELLS; RESIDENT NK CELLS; CD4(+) T-CELLS; ROR-GAMMA-T; TOXOPLASMA-GONDII; CUTTING EDGE; TERMINAL DIFFERENTIATION; GENE-EXPRESSION;
D O I
10.1146/annurev-cellbio-100818-125403
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.
引用
收藏
页码:381 / 406
页数:26
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