Trinuclear Ni(II), Pd(II) and Cu(II) complexes containing the 2-hydroxy-benzaldehyde-ferrocenyl-sulfonylhydrazone ligand: Synthesis, structural characterization and antiplasmodial evaluation

被引：11

作者：

Almendras, Ignacio ^{[1
]}

Huentupil, Yosselin ^{[1
]}

Novoa, Nestor ^{[1
]}

Roussel, Pascal ^{[2
]}

Melis, Diana R. ^{[3
]}

Smith, Gregory S. ^{[3
]}

Arancibia, Rodrigo ^{[1
]}

机构：

[1] Univ Concepcion, Fac Ciencias Quim, Dept Quim Analit & Inorgan, Lab Quim Inorgan & Organomet, Concepcion, Chile

[2] Univ Lille, Lille, France

[3] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

来源：

INORGANICA CHIMICA ACTA | 2019年 / 496卷

基金：

新加坡国家研究基金会; 芬兰科学院;

关键词：

Ferrocenyl-sulfonylhydrazone ligand; Trinuclear complexes; Antiplasmodial; ANTI-MYCOBACTERIUM-TUBERCULOSIS; IN-VITRO ANTIBACTERIAL; CRYSTAL-STRUCTURES; ANTIMALARIAL ACTIVITY; CARBONIC-ANHYDRASES; MOLECULAR-STRUCTURE; METAL-CARBONYLS; NICKEL(II); ELECTROCHEMISTRY; METHANESULFONYLHYDRAZONE;

D O I：

10.1016/j.ica.2019.119050

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The novel 2-hydroxy-benzaldehyde-ferrocenyl-sulfonylhydrazone ligand [(eta(5)-C5H5)Fe(eta(5)-C5H4SO2NH-N = CH-C6H4-2-OH)] (HL) and its nickel(II), palladium(II) and copper(II) complexes (1a-c) have been synthesized. All compounds were characterized using conventional spectroscopic and analytical techniques (infrared, H-1 and C-13 NMR, mass spectrometry and elemental analysis). The proposed molecular structures of HL, 1a and 1c were confirmed by single-crystal X-ray crystallography. The in vitro antiplasmodial activity of the new ligand and its corresponding metal complexes was evaluated against the chloroquine-sensitive (NF54) strain of the human malaria parasite, Plasmodium falciparum, and showed only modest activities in the micromolar range.

引用

页数：6

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