Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study

被引:54
作者
Crouthamel, Michelle [1 ]
Quattrocchi, Emilia [2 ]
Watts, Sarah [3 ]
Wang, Sherry [1 ]
Berry, Pamela [1 ]
Garcia-Gancedo, Luis [3 ]
Hamy, Valentin [2 ]
Williams, Rachel E. [1 ]
机构
[1] GlaxoSmithKline, 1000 Black Rock Rd, Collegeville, PA 19426 USA
[2] GlaxoSmithKline, Stockley Pk, Uxbridge, Middx, England
[3] GlaxoSmithKline, Stevenage, Herts, England
关键词
rheumatoid arthritis; smartphone; mobile phone; patient-reported outcome measures; mobile applications; QUALITY-OF-LIFE; DISEASE-ACTIVITY; SELF-ASSESSMENT; MOBILE HEALTH; RELIABILITY; MOTION; RANGE; SCALE;
D O I
10.2196/mhealth.9656
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: Using smartphones to enroll, obtain consent, and gather self-reported data from patients has the potential to enhance our understanding of disease burden and quantify physiological impact in the real world. It may also be possible to harness integral smartphone sensors to facilitate remote collection of clinically relevant data. Objective: We conducted the Patient Rheumatoid Arthritis Data From the Real World (PARADE) observational study using a customized ResearchKit app with a bring-your-own-device approach. Our objective was to assess the feasibility of using an entirely digital approach (social media and smartphone app) to conduct a real-world observational study of patients with rheumatoid arthritis. Methods: We conducted this observational study using a customized ResearchKit app with a bring-your-own-device approach. To recruit patients, the PARADE app, designed to guide patients through a series of tasks, was publicized via social media platforms and made available for patients in the United States to download from the Apple App Store. We collected patient-reported data, such as medical history, rheumatoid arthritis-related medications (past and present), and a range of patient-reported outcome measures. We included in the assessment a joint-pain map and a novel objective assessment of wrist range of movement, measured by the smartphone-embedded gyroscope and accelerometer. Results: Within 1 month of recruitment via social media campaigns, 399 participants self-enrolled, self-consented, and provided complete demographic data. Joint pain was the most frequently reported rheumatoid arthritis symptom to bother study participants (344/393, 87.5%). Severe patient-reported wrist pain appeared to be inversely linked with the range of wrist movement measured objectively by the app. At study entry, 292 of 399 participants (73.2%) indicated a preference for participating in a mobile app-based study. The number of participants in the study declined to 45 of 399 (11.3%) at week 12. Conclusions: Despite the declining number of participants over time, the combination of social media and smartphone app with sensor integration was a feasible and cost-effective approach for the collection of patient-reported data in rheumatoid arthritis. Integral sensors within smartphones can be harnessed to provide novel end points, and the novel wrist range of movement test warrants further clinical validation.
引用
收藏
页数:13
相关论文
共 32 条
[1]  
Anguera Joaquin A, 2016, BMJ Innov, V2, P14
[2]  
[Anonymous], 2017, NUMBER MOBILE PHONE
[3]  
Anton Stephen D, 2012, J Diabetes Sci Technol, V6, P1216
[4]  
Apple Inc, 2018, RESEARCHKIT
[5]   Smartphone application for rheumatoid arthritis self-management: cross-sectional study revealed the usefulness, willingness to use and patients' needs [J].
Azevedo, Rita ;
Bernardes, Miguel ;
Fonseca, Joao ;
Lima, Aurea .
RHEUMATOLOGY INTERNATIONAL, 2015, 35 (10) :1675-1685
[6]   Development of the Rheumatoid Arthritis Symptom Questionnaire (RASQ): a patient reported outcome scale for measuring symptoms of rheumatoid arthritis [J].
Banderas, Benjamin ;
Skup, Martha ;
Shields, Alan L. ;
Mazar, Iyar ;
Ganguli, Arijit .
CURRENT MEDICAL RESEARCH AND OPINION, 2017, 33 (09) :1643-1651
[7]   The mPower study, Parkinson disease mobile data collected using ResearchKit [J].
Bot, Brian M. ;
Suver, Christine ;
Neto, Elias Chaibub ;
Kellen, Michael ;
Klein, Arno ;
Bare, Christopher ;
Doerr, Megan ;
Pratap, Abhishek ;
Wilbanks, John ;
Dorsey, E. Ray ;
Friend, Stephen H. ;
Trister, Andrew D. .
SCIENTIFIC DATA, 2016, 3
[8]  
Bruce B, 2005, CLIN EXP RHEUMATOL, V23, pS14
[9]   The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit [J].
Chan, Yu-Feng Yvonne ;
Wang, Pei ;
Rogers, Linda ;
Tignor, Nicole ;
Zweig, Micol ;
Hershman, Steven G. ;
Genes, Nicholas ;
Scott, Erick R. ;
Krock, Eric ;
Badgeley, Marcus ;
Edgar, Ron ;
Violante, Samantha ;
Wright, Rosalind ;
Powell, Charles A. ;
Dudley, Joel T. ;
Schadt, Eric E. .
NATURE BIOTECHNOLOGY, 2017, 35 (04) :354-+
[10]  
DeLucca P, 2000, Biostatistics, V1, P107, DOI 10.1093/biostatistics/1.1.107