Autophagy and EMT in cancer and metastasis: Who controls whom?

被引：110

作者：

Gundamaraju, Rohit ^{[1
,14
]}

Lu, Wenying ^{[2
]}

Paul, Manash K. ^{[3
]}

Jha, Niraj Kumar ^{[4
,15
]}

Gupta, Piyush Kumar ^{[5
]}

Ojha, Shreesh ^{[6
]}

Chattopadhyay, Indranil ^{[7
]}

Rao, Pasupuleti Visweswara ^{[8
,9
,16
]}

Ghavami, Saeid ^{[10
,11
,12
,13
]}

机构：

[1] Univ Tasmania, Sch Hlth Sci, ER Stress & Mucosal Immunol lab, Launceston, Tas 7248, Australia

[2] Univ Tasmania, Sch Hlth Sci, Dept Lab Med, Resp Translat Res Grp, Launceston, Tas 7248, Australia

[3] UCLA, Dept Pulm & Crit Care Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

[4] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, UP, India

[5] Sharda Univ, Sch Basic Sci & Res, Dept Life Sci, Greater Noida 201310, Uttar Pradesh, India

[6] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Internal Med, Al Ain, U Arab Emirates

[7] Cent Univ Tamil Nadu, Dept Life Sci, Thiruvarur, Tamil Nadu, India

[8] Univ Malaysia Sabah, Fac Med & Hlth Sci, Dept Biomed Sci & Therapeut, Kota Kinabalu 88400, Sabah, Malaysia

[9] Abdurrab Univ, Fac Med & Hlth Sci, Dept Biochem, Pekanbaru, Riau, Indonesia

[10] Univ Manitoba, Fac Hlth Sci, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada

[11] Univ Manitoba, Res Inst Oncol & Hematol, Canc Care Manitoba, Winnipeg, MB R3E 0V9, Canada

[12] Shiraz Univ Med Sci, Autophagy Res Ctr, Shiraz 7134845794, Iran

[13] Katowice Sch Technol, Fac Med, PL-40555 Katowice, Poland

[14] Washington Univ, Dept Med, Div Gastroenterol, Sch Med, St Louis, MO USA

[15] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, India

[16] Reva Univ, Ctr Int relat & collaborat, Rukmini knowledge Pk, Bangalore 560064, Karnataka, India

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2022年 / 1868卷 / 09期

关键词：

Autophagy; Epithelial-Mesenchymal Transition (EMT); Metastasis; Starvation; Tumor signalling pathways; EPITHELIAL-MESENCHYMAL TRANSITION; E-CADHERIN EXPRESSION; INDUCED APOPTOSIS; CELL CARCINOMA; UNFAVORABLE PROGNOSIS; ANOIKIS RESISTANCE; PROSTATE-CANCER; INHIBITION; INVASION; MIGRATION;

D O I：

10.1016/j.bbadis.2022.166431

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis consists of hallmark events, including Epithelial-Mesenchymal Transition (EMT), angiogenesis, initiation of inflammatory tumor microenvironment, and malfunctions in apoptosis. Autophagy is known to play a pivotal role in the metastatic process. Autophagy has pulled researchers towards it in recent times because of its dual role in the maintenance of cancer cells. Evidence states that cells undergoing EMT need autophagy in order to survive during migration and dissemination. Additionally, it orchestrates EMT markers in certain cancers. On the other side of the coin, autophagy plays an oncosuppressive role in impeding early metastasis. This review aims to project the interrelationship between autophagy and EMT. Targeting EMT via autophagy as a useful strategy is discussed in this review. Furthermore, for the first time, we have covered the possible reciprocating roles of EMT and autophagy and its consequences in cancer metastasis.

引用

页数：11

共 148 条

[71] Inhibition of autophagy impairs tumor cell invasion in an organotypic model [J].