Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

被引：41
作者：
Jiang, Lin-Hua [1 ]
Caseley, Emily A. [1 ,2 ]
Muench, Steve P. [1 ]
Roger, Sebastien [3 ]
机构：
[1] Univ Leeds, Fac Biol Sci, Sch Biomed Sci, Leeds, W Yorkshire, England
[2] St James Univ Hosp, Fac Med & Hlth, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
[3] Univ Tours, Fac Med, EA4245, Transplantat Immunol & Inflammat, Tours, France
来源：
PURINERGIC SIGNALLING | 2021年 / 17卷 / 03期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
Agonist binding; Receptor activation; Ion permeation; Large pore formation; Antagonism; AMINO-ACID-RESIDUES; P2X(7) RECEPTOR; ION-CHANNEL; PHARMACOLOGICAL CHARACTERIZATION; DIFFERENTIAL SENSITIVITY; IDENTIFICATION; ANTAGONISTS; BINDING; RAT; ACTIVATION;
D O I：
10.1007/s11302-021-09790-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure-function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.
引用
收藏
页码：331 / 344
页数：14
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