Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

被引：41
作者：
Jiang, Lin-Hua [1 ]
Caseley, Emily A. [1 ,2 ]
Muench, Steve P. [1 ]
Roger, Sebastien [3 ]
机构：
[1] Univ Leeds, Fac Biol Sci, Sch Biomed Sci, Leeds, W Yorkshire, England
[2] St James Univ Hosp, Fac Med & Hlth, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
[3] Univ Tours, Fac Med, EA4245, Transplantat Immunol & Inflammat, Tours, France
来源：
PURINERGIC SIGNALLING | 2021年 / 17卷 / 03期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
Agonist binding; Receptor activation; Ion permeation; Large pore formation; Antagonism; AMINO-ACID-RESIDUES; P2X(7) RECEPTOR; ION-CHANNEL; PHARMACOLOGICAL CHARACTERIZATION; DIFFERENTIAL SENSITIVITY; IDENTIFICATION; ANTAGONISTS; BINDING; RAT; ACTIVATION;
D O I：
10.1007/s11302-021-09790-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure-function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.
引用
收藏
页码：331 / 344
页数：14
相关论文
共 81 条
[1]   The P2X7 receptor: A main player in inflammation [J].
Adinolfi, Elena ;
Giuliani, Anna Lisa ;
De Marchi, Elena ;
Pegoraro, Anna ;
Orioli, Elisa ;
Di Virgilio, Francesco .
BIOCHEMICAL PHARMACOLOGY, 2018, 151 :234-244
[2]   Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor [J].
Adinolfi, Elena ;
Cirillo, Maria ;
Woltersdorf, Ronja ;
Falzoni, Simonetta ;
Chiozzi, Paola ;
Pellegatti, Patrizia ;
Callegari, Maria Giulia ;
Sandona, Doriana ;
Markwardt, Fritz ;
Schmalzing, Guenther ;
Di Virgilio, Francesco .
FASEB JOURNAL, 2010, 24 (09) :3393-3404
[3]   Cutting edge: A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor [J].
Adriouch, S ;
Dox, C ;
Welge, V ;
Seman, M ;
Koch-Nolte, F ;
Haag, F .
JOURNAL OF IMMUNOLOGY, 2002, 169 (08) :4108-4112
[4]   ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site [J].
Adriouch, Sahil ;
Bannas, Peter ;
Schwarz, Nicole ;
Fliegert, Ralf ;
Guse, Andreas H. ;
Seman, Michel ;
Haag, Friedrich ;
Koch-Nolte, Friedrich .
FASEB JOURNAL, 2008, 22 (03) :861-869
[5]   Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7 [J].
Adriouch, Sahil ;
Scheuplein, Felix ;
Baehring, Robert ;
Seman, Michel ;
Boyer, Olivier ;
Koch-Nolte, Friedrich ;
Haag, Friedrich .
PURINERGIC SIGNALLING, 2009, 5 (02) :151-161
[6]   P2X7 receptors: role in bone cell formation and function [J].
Agrawal, Ankita ;
Gartland, Alison .
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2015, 54 (02) :R75-R88
[7]   Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors [J].
Allsopp, Rebecca C. ;
Dayl, Sudad ;
Bin Dayel, Anfal ;
Schmid, Ralf ;
Evans, Richard J. .
MOLECULAR PHARMACOLOGY, 2018, 93 (05) :553-562
[8]   Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120 [J].
Allsopp, Rebecca C. ;
Dayl, Sudad ;
Schmid, Ralf ;
Evans, Richard J. .
SCIENTIFIC REPORTS, 2017, 7
[9]   Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels [J].
Allsopp, Rebecca C. ;
Evans, Richard J. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (23) :14556-14566
[10]   The P2X7 Receptor: Central Hub of Brain Diseases [J].
Andrejew, Roberta ;
Oliveira-Giacomelli, Agatha ;
Ribeiro, Deidiane Elisa ;
Glaser, Talita ;
Arnaud-Sampaio, Vanessa Fernandes ;
Lameu, Claudiana ;
Ulrich, Henning .
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2020, 13
123456789